Gene ML0214
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP phosphoribosyltransferase) (IMP diphosphorylase) (transphosphoribosyltransferase) (guanine phosphoribosyltransferase) |
| Comments | ML0214, len: 213 aa. Probable hpt (alternate gene name: hprT), hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8), highly similar to other mycobacterial hypoxanthine-guanine phosphoribosyltransferases e.g. Rv3624c|HPRT_MYCTU|O06383 from M. tuberculosis (216 aa), Fasta scores: E(): 0, (83.1% identity in 207 aa overlap); and P96794|HPRT_MYCAV from M. avium (203 aa). And similar to many other bacterial hypoxanthine phosphoribosyltransferases e.g. O33799|AF008931 from Salmonella typhimurium (178 aa), Fasta scores: E(): 9.6e-32, (50.9% identity in 169 aa overlap). Previously sequenced as O69537|AL023093 (213 aa), Fasta scores: E(): 0, (99.5% identity in 213 aa overlap). Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature. Belongs to the purine/pyrimidine phosphoribosyltransferase family |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 285584 | 286225 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0214|hpt
VVFRRAAWHALLVAQSFSAINPGPTAELYLGDIKSVMLTQEQIQARIAELGAQIGHDYRDRSPASDQDLLLVTVLKGAVIFVTDLARAIPLPTQFEFMAVSSYGSSMSSSGVVRILKDLDRDIHDRNVLIVEDVVDSGLTLSWLLRNLATRRPQSLQVCTLLRKPDALRANVDITYVGFDIPNDFVVGYGLDYDERYRDLPYIGMLDPRVYQQ
Bibliography
No article yet recorded
