Gene ML0222
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable membrane-bound protease FtsH (cell division protein) |
| Comments | ML0222, len: 790 aa. Probable ftsH, membrane-bound protease (cell division protein) (EC 3.4.24.-) (see citations below), highly similar to Rv3610c|FTSH_MYCTU|P96942 ftsH, membrane-bound protease from M. tuberculosis (760 aa), Fasta scores: E(): 0, (87.2% identity in 790 aa overlap). Similar to many others e.g. FTSH_ECOLI|P28691 ftsH, cell division protein from Escherichia coli (644 aa), Fasta scores: E(): 0, (49.3% identity in 611 aa overlap). Previously sequenced as O69532|AL023093 (787 aa), Fasta scores: E(): 0, (100.0% identity in 787 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01434 Peptidase_M41, Peptidase family M41. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00674 AAA-protein family signature. Belongs to the AAA family of ATPase and peptidase family M41 (zinc metalloproteases). Cofactor: potentially binds one zinc ion. |
| Functional category | Cell wall and cell processes |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 293693 | 296065 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0222|ftsH
MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAMSQINGHNVKSAQIDDREQQLRLTLKKGNNDTDGSDKVITKYPTGYAVDLFNALSAKNTKVTTAVNEGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPCRYQTLGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFDQAKQNSPCIIFVDEIDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPIADDADLDGLAKRTVGMTGADLANVVNEAALLTARENGLVITGPALEEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTTGAVSDIEKATKIARSMVTEFGMSSKLGAVRYGSEHGDPFLGRTMGTQADYSHEVARDIDDEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPELEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPVPEPAFKAAIARASQAAEASHQAAQSDTDGPPGQGANGSHAGDRQRQHGPTQPDYGAPPGWHAPGWPPQQPPDYWYPPEQQPSQSPYWPQPAPSYPGQAPPPYPSYPPCPSYPPPGQSAPDAGKPPAQLDEGVSPSNPPAHG
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