Gene ML0225
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in folate biosynthesis. Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin [Catalytic activity: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde]. |
| Product | Probable dihydroneopterin aldolase FolB (DHNA) |
| Comments | ML0225, len: 132 aa. Probable folB, dihydroneopterin aldolase (EC 4.1.2.25), highly similar to Rv3607c|FOLB_MYCTU|O06275 probable folB, dihydroneopterin aldolase from M. tuberculosis (133 aa), Fasta scores: E(): 0, (74.8% identity in 131 aa overlap). Similar to many others e.g. FOLB_STAAU|P56740 folB, dihydroneopterin aldolase from Staphylococcus aureus (121 aa), Fasta scores: E(): 1.9e-09, (33.9% identity in 121 aa overlap). Previously sequenced as FOLB_MYCLE|O69529 (132 aa), Fasta scores: E(): 0, (100.0% identity in 132 aa overlap). Contains Pfam match to entry PF02152 FolB, Dihydroneopterin aldolase. Belongs to the DHNA family. |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 297543 | 297941 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0225|folB
MADRMELRGLIVRGRHGVYEVERANGQDFIVDVILWIDLADAAANDNLADTYDYVVLAERTAAIIAGPPRNLIETVGSEIADFVMDDERVHAVEVVVHKPQAPIPQQFSDVAVVVRRSRRGGRGSMIPASGV
Bibliography
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