Gene ML0226
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7,8-dihydropterin diphosphokinase) |
| Comments | ML0226, len: 191 aa. Probable folK, 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase (EC 2.7.6.3), highly similar to Rv3606c|HPPK_MYCTU|O06276 folK, 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase from M. tuberculosis (188 aa), Fasta scores: E(): 0, (63.2% identity in 190 aa overlap). Similar to many others e.g. to the C-terminal half of SULD_STRPN|P22291 sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase) from Streptococcus pneumoniae (270 aa), Fasta scores: E(): 1.8e-07, (37.8% identity in 135 aa overlap). Previously sequenced as HPPK_MYCLE|O69528 (191 aa), Fasta scores: E(): 0, (100.0% identity in 191 aa overlap). Contains Pfam match to entry PF01288 HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Contains PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. Belongs to the HPPK family. |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 297941 | 298516 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0226|folK
MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAVEQRSFLNAVVIADGPAYDTKAWLCRAQELERNAGRVRGQRWGARTLDVDLISCYQTSGATTGAVEVITCESNLTLPHPRAHLRAFVLVPWLAVDSDAELTVAGRAQRVDRLLAEMEPTEREGVRLTNLTLKLKRSSPARPVSPKSD
Bibliography
No article yet recorded
