Gene ML0252
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Necessary for strand-specific repair. a lesion in the template stand blocks the RNA polymerase complex (RNAp). The RNAp-DNA-RNA complex is specifically recognized by mfd which releases RNAp and the truncated transcript; the mfd may replace RNAp at the lesion site and then recruit the uvrA/B/C repair system. |
| Product | Probable transcription-repair coupling factor Mfd (trcF) |
| Comments | ML0252, len: 1224 aa. Probable mfd, transcription-repair coupling factor, highly similar to Rv1020|MFD_MYCTU|P96380 mfd, transcription-repair coupling factor from M. tuberculosis (1234 aa), Fasta scores: E(): 0, (84.3% identity in 1229 aa overlap); and similar to many others e.g. MFD_ECOLI|P30958 mfd, transcription-repair coupling factor from Escherichia coli (1148 aa), Fasta scores: E(): 0, (38.1% identity in 1111 aa overlap). Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. In the N-terminal section; belongs to the uvrB family and in the C-terminal section; belongs to the helicase family. recG subfamily. |
| Functional category | Information pathways |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 328067 | 331741 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0252|mfd
MTAPGPACLDTPIAGLVELALTAPTFGQLMERAGTRPAELILAGPACARLFVASALARLGPLLVVTATGREASNLTAELRGVFGAAVAMFPSWETLPHERLSPGVDTVGARLMVLRRLAHPDDARLGPPLQVVVTAVRSLLQPMTAQLGLVEPVTLSVGDEIGFERVIARLVELAYTRVDMVGRRGEFAVRGGILDIFGPTAEHPVRVEFWGDEITEMRMFSVVDQRSIPEIGVDTLVAIACRELLLSDDVRARAVELAAQAAARRPTEEPAISGSVTDVLAKLAEGIPVDGMEALLPVLCPDDYALLTDQFAADTPVLLCDPEKVRIQAADLIKTDRAFLEASWSVAAIGADNAAPVDVEQLYGSGFVELGDVQAAAIRSGHPWWTLSQLSDESALELDIRAAPSTRGHQHAIDGIFAMLRAHVATGGYAAIVTPGTGTAHRVVERLAESDIPGAMLEPAAAPGLGLRPGLVGVLKGPLLDGVVIPGANLVIITEADLTGSRATPVEGKRLAAKRRSAADPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASNKKSKQADKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARCAVREIAGELVSLYAKRQASPGHAFGPDTPWQAEMEDAFGFTETVDQLTAITEVKGDMEKSVPMDRVICGDVGYGKAEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLRTFTERMAGFPVTVKGLSRFTDAAESRAVIDGLAEGSVDIVIGTHRLLQTGVCWKDLGLVVVDEEQWFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQVAAALRRELLRDGQAFYVHNRVSSIYQAAARVCGLVPEARVVVAHGQMPEDLLETTMRGFWNREYDILVCTTIVETGLDIPNANTLVVERADTFGLSQLHQLRGRVGRSHERGYAYFLYPPQAPLTEIAYDRLVTIAQNNELGAGMAVALKDLEIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYRAVADGKTAITPEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDTEVAAVVDELIDRYGALPEPAQRLVAVAQLRLLCRGSGIIEVTAPSASTMRLSPIRLIDSAQVRLKRMYPGAQYRATAATVQVPIPRAGSSGGTLGVPCIRDVELVQAVADLITALQGLPRKVIGITGPEPTSK
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