Gene ML0295 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethiD
Gene length840 bp
IdentifierML0295
Location 379127 bp
Protein summary information
Molecular mass28950.9 Da
Isoelectric point5.5
Protein length280 amino acids
Structural information
PFAMPF08543
Orthologs
M. tuberculosis H37RvRv0422c
M. lepromatosis Mx1-22AMLPM_0295
Cross-references
UniProtQ9ZBL1
Gene OntologyPhosphomethylpyrimidine kinase activity, Thiamine biosynthetic process, Atp binding
Enzyme Classification2.7.4.7
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable phosphomethylpyrimidine kinase ThiD
CommentsML0295, len: 279 aa. Probable thiD, phosphomethylpyrimidine kinase (EC 2.7.4.7), highly similar to Rv0422c|THID_MYCTU|P96268 thiD, phosphomethylpyrimidine kinase from M. tuberculosis (265 aa), Fasta scores: E(): 0, (77.8% identity in 266 aa overlap). Similar to many others e.g. THID_ECOLI|P76422 thiD, phosphomethylpyrimidine kinase from Escherichia coli (266 aa), Fasta scores: E(): 3.2e-29, (38.4% identity in 263 aa overlap). Previously sequenced as THID_MYCLE|Q9ZBL1 (279 aa), Fasta scores: E(): 0, (99.6% identity in 279 aa overlap). Belongs to the ThiD family.
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS379127379966+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0295|thiD
VNYLPAPPPGTTPLRVLSIAGSDSGGGAGIQADMRTMTVLGVHACTAVTAVTIQNTLGVEGFHEIPAEIVASQIKAVVTDIGIQSAKTGMLASSSIIAAVAETWLRLELTTPLVVDPVCASMHGDPLLTGEAMDSLRDRLFPLATVVTPNLDEVRLLVGIDVVDTESQRAAAMALHALGPQWALVKGGHLRSSDRSCDLLYGGSSAGVAFHEFDAPRVQTGNDHGGGDTLAAAVSCALAHGYTVPDAVGFGKRWVTECLRDAYPLGRGHGPVSPLFQRT
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