Gene ML0317 (groL2, groEL-2, hsp65, hsp60)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | 65 kDa chaperonin 2 GroEL2 (Protein Cpn60-2) (groEL protein 2) (65 kDa antigen) (Heat shock protein 65) (Cell wall protein A) (Antigen A). |
| Comments | ML0317, len: 541 aa. Probable groEL2 (alternate gene names: groL2, groEL-2, hsp65, hsp60), 65 kDa chaperonin 2 (see citations below), highly similar to Rv0440|CH62_MYCTU|P06806 groEL2, 60 kDa chaperonin 2 from M. tuberculosis (539 aa), Fasta scores: E(): 0, (94.8% identity in 541 aa overlap); and other bacterial chaperonin proteins. Previously sequenced as CH62_MYCLE|P09239 (540 aa), Fasta scores: E(): 0, (100.0% identity in 540 aa overlap). Also similar to ML0381 from M. leprae. Contains Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family. Contains PS00296 Chaperonins cpn60 signature. In M. tuberculosis purified 65 kDa antigen can elicit a strong delayed-type hypersensitivity reaction when infected in experimental animals. This protein is one of the major immunoreactive proteins of mycobacteria. This antigen contains epitopes that are common to various species of mycobacteria. Belongs to the chaperonin (hsp60) family. |
| Functional category | Virulence, detoxification, adaptation |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 405519 | 407144 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0317|groEL2
MAKTIAYDEEARRGLERGLNSLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGANPLGLKRGIEKAVDKVTETLLKDAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDAERQEAVLEEPYILLVSSKVSTVKDLLPLLEKVIQAGKSLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGAQVISEEVGLTLENTDLSLLGKARKVVMTKDETTIVEGAGDTDAIAGRVAQIRTEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPALDKLKLTGDEATGANIVKVALEAPLKQIAFNSGMEPGVVAEKVRNLSVGHGLNAATGEYEDLLKAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKTAAPASDPTGGMGGMDF
Bibliography
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