Gene ML0323 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namecysS1
Gene length1422 bp
IdentifierML0323
Location 412124 bp
Protein summary information
Molecular mass52092.6 Da
Isoelectric point5.9
Protein length474 amino acids
Structural information
PFAMPF01406, PF09190
Orthologs
M. tuberculosis H37RvRv3580c
M. lepromatosis Mx1-22AMLPM_0323
Cross-references
UniProtP57990
Gene OntologyCysteine-trna ligase activity, Cysteinyl-trna aminoacylation, Cytoplasm, Zinc ion binding, Atp binding
Enzyme Classification6.1.1.16
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable cysteinyl-tRNA synthase 1 CysS1 (Cysteine--tRNA ligase 1) (CysRS 1)
CommentsML0323, len: 473 aa. Probable cysS1, cysteinyl-tRNA synthetase (EC 6.1.1.16), highly similar to Rv3580c|SYC1_MYCTU|P96862 cysS1, cysteinyl-tRNA synthetase from M. tuberculosis (469 aa), Fasta scores: E(): 0, (86.5% identity in 467 aa overlap). Similar to many others e.g. SYC_ECOLI|P21888 cysS, cysteinyl-tRNA synthetase from Escherichia coli (461 aa), Fasta scores: E(): 0, (42.0% identity in 460 aa overlap). Also similar to ML1302 from M. leprae. Contains Pfam match to entry PF01406 tRNA-synt_1e, tRNA synthetases class I (C). Belongs to the class-I aminoacyl-tRNA synthetase family. Strongly similar to methionyl-tRNA synthetase.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS412124413545+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0323|cysS1
VIDSGHLRLHDTVAGAVRDFVPLRAGHVSIYLCGATVQGQPHIGHVRSGVAFDILRRWLMARGYDVAFIRNVTDIDDKILNKAAAAGRPWWEWAATHERAFTAAYDALDVLPPSAEPRATGHITQMIELIELLIETGHAYTGGSDVYFDVLSYPDYGQLSGHKMDYIHQGEGVTTGKRDQRDFTLWKGAKSGEPSWPTPWGRGRPGWHLECSAMARAYLGSEFDIHCGGMDLVFPHHENEIAQSRAVGDGFARYWLHNGWVTMGGEKMSKSLGNVLSIPAVLQRVRPAELRYYLGSAHYRSMLEFSEAALQDAVKAYVGVENFLTRVRTRVGAVGTGELTPRFAAALDDDLAVPIALAEVHHARVEGNRALDIGDHEGALTNAGAIRAMMGILGCDPLDERWESRDETSAALAAVDVLVAAELESRQMAREQRNWVLADQIRDRLKDAGIEVTDTVNGPQWELLAGDKQVDAR
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