Gene ML0354
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable acetohydroxyacid synthase IlvX (acetolactate synthase) |
| Comments | ML0354, len: 515 aa. Probable ilvX, acetohydroxyacid synthase (EC 4.1.3.18), highly similar to Rv3509c|O53554|AL123456 ilvX, probable acetohydroxyacid synthase from M. tuberculosis (515 aa), Fasta scores: E(): 0, (82.9% identity in 515 aa overlap). Also similar to various enzymes (principally acetohydroxyacid/acetolactate synthases) e.g. ILVI_ECOLI|P00893 ilvI, acetolactate synthase isozyme III large subunit from Escherichia coli (574 aa), Fasta scores: E(): 1.8e-07, (23.7% identity in 540 aa overlap); and MDLC_PSEPU|P20906 mdlC, benzoylformate decarboxylase from Pseudomonas putida (528 aa), Fasta scores: E(): 6.6e-13, (29.3% identity in 529 aa overlap). Previously sequenced as Q49865|U00020 (515 aa), Fasta scores: E(): 0, (99.8% identity in 515 aa overlap). Contains 2 Pfam matches to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 447415 | 448962 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0354|ilvX
VNGAQAMISTLVDGGVDVCFANPGTSEMHFVAALDTVAGMRGVLTLFEGVATGAADGYARIAGRPAVVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDALAGTVSGWLHRTMDTADVGVDAAEAISASLVGSQISTLILPADVSWSDGAIPAASVSDQPASAGVDVGAVRTALESGEPTVILIGADATGWSGLAAVARIGAATGARWFCETFPARLERGAGVPAVERLAYFAEVAAAQLDGAKHLVLAGAQSPVSFFAYPGMPSDLVPAGCEVHVLAEHGGAAYALNALADEVASGTAAPVVAASRPQLPSGPLTSGAAANVIGALLPERAIVVDESNTSGVLLAAATAGAPAHDWLTLTGGAIGHGIPASVGAAVAAPDRPVLCLESDGSAMYTISGLWTQARENLDVTTIIYNNGAYNILRIELQRMGAGSTPGPKALSLLDLSSPTMDFVKIAEGMGVSARRVNTTEGLADALRLAFTEPGPHLIDTVVPSIVG
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