Gene ML0366
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable phospho-sugar mutase / MrsA protein homolog |
| Comments | ML0366, len: 463 aa. Probable mrsA, phosphoglucomutase or phosphomannomutase (EC 5.4.2.-), highly similar to Rv3441c|O06258|AL123456 mrsA, phosphoglucomutase or phosphomannomutase from M. tuberculosis (448 aa), Fasta scores: E(): 0, (87.6% identity in 445 aa overlap). Similar to many other phospho-sugar mutases e.g. Q53876|SC6G4.14 putative phospho-sugar mutase (similar to phosphomannomutase) from Streptomyces coelicolor (452 aa), Fasta scores: E(): 0, 59.3% identity in 452 aa overlap) and MANB_SALTY|P26341 manB, phosphomannomutase from Salmonella typhimurium (264 aa), and Q9KG46|BH0267 phosphoglucosamine mutase from Bacillus halodurans (447 aa), Fasta scores: E(): 0, (47.2% identity in 445 aa overlap). Previously sequenced as Q49869|U00020 (463 aa), Fasta scores: E(): 0, (100.0% identity in 463 aa overlap). Also similar to ML0706 and ML0763 from M. leprae. Contains Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. Belongs to the phosphohexose mutases family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 457993 | 459384 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0366|mrsA
MGRLFGTDGVRGVANRELTPELVLALGAAAARCLANSGEPGRRVAVIGRDPRASGEMLEAAVIAGLTSAGVDALRVGVLPTPAVAYLTGAYDADFGVMISASHNPMVDNGIKIFGPGGHKLDDDTEDQIEDLVTGGPGLRPAGVAIGRVIDAEDATERYLRHVGKASTIRLDGLTVVVDCAHGAASSAAPRAYRAAGARVIAINADPNGININDRCGSTDLGSLRSAVLAHRADLGLAHDGDADRCLAVDANGDLVDGDAIMVVLALAMQEAGELSSNTLVTTVMSNLGLHLAMRSVGVIVRTTDVGDRYVLEELRAGDFSLGGEQSGHIVMPALGSTGDGIITGLRLMTRMVQTSSSLAALASAMRALPQVLINVEVADKTTAAAAPLVQTAVETAEVELGNTGRILLRPSGTEPMIRVMVEAAEEDVAHRVATRVAAAVSAQGSPLRCWNPDAISGVELRL
Bibliography
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