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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductProbable alanine racemase Alr
CommentsML0375, len: 388 aa. Probable alr, alanine racemase (EC 5.1.1.1), highly similar to Rv3423c|ALR_MYCTU|Q50705 alr, probable alanine racemase from M. tuberculosis (408 aa), Fasta scores: E(): 0, (84.6% identity in 382 aa overlap). Highly similar to other alanine racemases e.g. ALR_MYCSM|P94967 alr, alanine racemase from Mycobacterium smegmatis (389 aa), Fasta scores: E(): 0, (67.2% identity in 378 aa overlap); and O86786|ALR_STRCO|SC6G4.23 from Streptomyces coelicolor (391 aa). Previously sequenced as ALR_MYCLE|P38056 (388 aa), Fasta scores: E(): 0, (99.7% identity in 388 aa overlap). Contains 2 Pfam matches to entry PF00842 Ala_racemase, Alanine racemase. Belongs to the alanine racemase family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS468133469299+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0375|alr
LAVTPISLRPGVLAEAVVDLGAIDYNVRVLREHAGMAQLMVVLKADAYGHGATQVALAALAAGAAELGVATVDEALALRADGISAPVLAWLHPPGIDFGPALLADVQIAVSSVRQLDELLDAVRRTGRTATVTVKADTGLNRNGVVTDQYPAMLTALQRAVVEDAVRLRGLMSHLVYADQPDNPSNDVQGKRFAALLAQAHEQGLRFEVAHLSNSSATMSRPDLAYDLVRPGIAVYGLSPVPSRGDMGLIPAMTVKCAVAMVKSIRAGEGVSYGHDWIAQHDTNLALLPVGYADGVFRSLGGRLDVLINGKRRPGVGRICMDQFVVDLGPGPIDVAEGDEAILFGPGARGEPTAQDWADLLGTIHYEVVTSLRGRITRTYREAQTVDR
      
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