Gene ML0387 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameguaB2
Gene length1590 bp
IdentifierML0387
Location 480662 bp
Protein summary information
Molecular mass54813.9 Da
Isoelectric point6.61
Protein length530 amino acids
Structural information
PFAMPF00478, PF00571
Orthologs
M. tuberculosis H37RvRv3411c
M. lepromatosis Mx1-22AMLPM_0387
Cross-references
UniProtQ49729
Gene OntologyImp dehydrogenase activity, Oxidation-reduction process, Potassium ion binding, Gmp biosynthetic process
Enzyme Classification1.1.1.205
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)
CommentsML0387, len: 529 aa. Probable guaB2, inosine-5'-monophosphate (IMP) dehydrogenase (EC 1.1.1.205), highly similar to Rv3411c|IMDH_MYCTU|Q50715 guaB2, probable inosine-5'-monophosphate dehydrogenase from M. tuberculosis (529 aa), Fasta scores: E(): 0, (92.4% identity in 529 aa overlap). Similar to many others e.g. IMDH_ECOLI|P06981 guaB, inosine-5'-monophosphate dehydrogenase from Escherichia coli (488 aa), Fasta scores: E(): 0, (54.3% identity in 490 aa overlap). Previously sequenced as IMDH_MYCLE|Q49729 (529 aa), Fasta scores: E(): 0, (100.0% identity in 529 aa overlap). Also similar to ML2066 and shows weaker similarity to ML0388 from M. leprae. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Contains Pfam match to entry PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus. Similar to other eukaryotic and prokaryotic IMPDH and to GMP reductase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS480662482251+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0387|guaB2
MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDVLLLPAASDVVPATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIAMARAGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVVDDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTEQHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR
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