Gene ML0388
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (IMP oxidoreductase) (IMPD) (IMPDH) |
| Comments | ML0388, len: 370 aa. Probable guaB3, inosine-5'-monophosphate (IMP) dehydrogenase (EC 1.1.1.205), equivalent to Rv3410c|YY10_MYCTU|Q50716 guaB3, probable inosine-5'-monophosphate dehydrogenase from M. tuberculosis (375 aa), Fasta scores: E(): 0, (90.5% identity in 368 aa overlap). This ORF is similar in part to ML0387 and ML2066 from M. leprae, which more closely resemble the experimentally characterised IMP-DH's (e.g. from Escherichia coli). This shorter homologue is conserved in several bacterial genera e.g Q9L0I6 putative inosine-5'-monophosphate dehydrogenase from Streptomyces coelicolor A3(2) (374 aa), Fasta scores: E(): 0, (52.2% identity in 368 aa overlap). Previously sequenced as YY10_MYCLE|U00015 (375 aa), Fasta scores: E(): 0, (100.0% identity in 370 aa overlap). Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Similar to other eukaryotic and prokaryotic IMPDH and to GMP reductase. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 482275 | 483387 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0388|guaB3
MGRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHADVGAKVAQLIEAAEKEPEPATAVCLLQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQNAQVLTPVLLAAGIDLLVVQGSIVSAECVASGGEPLNLKTFISELDVPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTRGATTSDEVLGISVPMATAIADAAAARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADAVVLGTPLAQSAEALGGGWFWPAAAAHPSLPRGALLQTAVGERPSLQQVLNGPSDNPFGTLNLVGGLRRSMAKAGYCDLKEFQKVGLIVSI
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