Gene ML0414c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in osmoregulatory trehalose biosynthesis. Mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [Catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]. |
| Product | Possible trehalose-6-phosphate phosphatase OtsB2 (Trehalose-phosphatase) (TPP) |
| Comments | ML0414c, len: 429 aa. Possible otsB2, trehalose-6-phosphate phosphatase (EC 3.1.3.12), highly similar to Rv3372|O50401|AL123456 otsB2, trehalose-6-phosphate phosphatase from M. tuberculosis (391 aa), Fasta scores: E(): 0, (67.1% identity in 425 aa overlap). Also weakly similar to several trehalose phosphatases e.g. except at N-terminus, to O64897|AF007779 tppB, trehalose-6-phosphate phosphatase from Arabidopsis thaliana (374 aa), Fasta scores: E(): 2.2e-17, (31.1% identity in 315 aa overlap). Previously sequenced as Q49734|U00015 (429 aa), Fasta scores: E(): 0, (100.0% identity in 429 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. |
| Functional category | Virulence, detoxification, adaptation |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 511985 | 513274 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0414c|otsB2
MPVTIDPRRHSAALFDLDAVVTDTPLDSTVTLVRQLQGIGVGTAVFSTNRNSQGVLTATGLDHLFPVHVDGLASGKVTILVAAANRLMAQPGRCVVVAVDAAGITAARYGGFALVLGLVIGEDQTGHRDTLRNSGADTVVADLGEVIVRTGDRRMSELPDALQTLGLTDDLTARQPAVFFDFDGTLSDIVDDPDSARPVPGATEALQKLATHCPVAILSGRDLADVIKRIGVPGIWYSGSHGFESTAPDGTHHQNDAAEATIPILEQAATQLRDQLGPIPGVMVEHKRFGVAVHYRNVARDRVNEVAVAVRTAGQRNALRVTTGREVIELRPDIDWDKGKTLHWVIDRLHHAGTQVGSASLMPICLGDDITDEDAFDAVRHTDVGGIPIVVRHTEDGNRATAALFTLDSPMHVSEFTERLARQLSDTQR
Bibliography
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