Gene ML0419c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase) |
| Comments | ML0419c, len: 158 aa. Probable spoU, tRNA/rRNA methylase (EC 2.1.1.-), highly similar to Rv3366|O50394|AL123456 spoU, possible RNA methyltransferase from M. tuberculosis (154 aa), Fasta scores: E(): 0, (83.8% identity in 154 aa overlap). Also similar to many members of the spoU family of rRNA methylases e.g. TRMH_ECOLI|P19396 spoU, tRNA (guanosine-2'-o-)-methyltransferase from Escherichia coli (229 aa), Fasta scores: E(): 4e-05, (30.4% identity in 148 aa overlap); and Q9K199|NMB0268 RNA methyltransferase (TRMH family) from Neisseria meningitidis (serogroup B) (154 aa). Previously sequenced as O07698|Z97179 (169 aa), Fasta scores: E(): 0, (100.0% identity in 158 aa overlap). Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family. Belongs to the RNA methyltransferase TRMH family. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 518415 | 518891 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0419c|spoU
MISKMFRLLFYTPRIPPNTGNAIRTAAVTGCALHLVEPIGFDLSNPKLRRAGLDYHDLASVTVHTSLSEAWNALSPARVFAFSTLANTLFTDVSYQAGDVLMFGPEPTGLDAATLADDHITQQVRIPMLSGRRSLNLSNAAAVAVYEAWRQHGYAGLV
Bibliography
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