Gene ML0482
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | FORMS A COMPLEX WITH RUVB. RUVA STIMULATES, IN THE PRESENCE OF DNA, THE WEAK ATPASE ACTIVITY OF RUVB. THE RUVA-RUVB COMPLEX IN THE PRESENCE OF ATP RENATURES CRUCIFORM STRUCTURE IN SUPERCOILED DNA WITH PALINDROMIC SEQUENCE, INDICATING THAT IT MAY PROMOTE STRAND EXCHANGE REACTIONS IN HOMOLOGOUS RECOMBINATION. RUVAB IS AN HELICASE THAT MEDIATES THE HOLLIDAY JUNCTION MIGRATION BY LOCALIZED DENATURATION AND REANNELING. |
| Product | Probable Holliday junction DNA helicase component RuvA |
| Comments | ML0482, len: 203 aa. Probable ruvA, Holliday junction binding protein (see citations below), highly similar to Rv2593c|RUVA_MYCTU|Q50628 ruvA, Holliday junction DNA helicase from M. tuberculosis (196 aa), Fasta scores: E(): 0, (76.4% identity in 203 aa overlap). Also highly similar to others e.g. Q9L290|RUVA from Streptomyces coelicolor (201 aa), FASTA scores:E(): 3.7e-29,(47.500% identity in 200 aa overlap); and Q9AE10|RUVA from Corynebacterium glutamicum (Brevibacterium flavum) (206 aa), fasta scores: E(): 1.6e-26, (44.762% identity in 210 aa overlap). Previously sequenced as RUVA_MYCLE|P40832 (203 aa), Fasta scores: E(): 0, (99.5% identity in 203 aa overlap). Contains Pfam match to entry PF01330 RuvA, Bacterial DNA recombination protein, RuvA. Belongs to the ruvA family. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 581788 | 582399 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0482|ruvA
VIFSVRGEVLEVALDHAVIEAAGIGYRVNATPSALATLRQGSQARLVTAMVVREDSMTLYGFSDAENRDLFLALLSVSGVGPRLAMATLAVHDAAALRQALADSDVASLTRVPGIGKRGAERIVLELRDKVGPVGASGLTVGTAADGNAVRGSVVEALVGLGFAAKQAEEATDQVLDGELGKDGAVATSSALRAALSLLGKTR
Bibliography
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