Gene ML0491
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN THE METABOLISM OF PPGPP (AT THE FIRST STEP). IN EUBACTERIA PPGPP (GUANOSINE 3'-DIPHOSPHATE 5-'DIPHOSPHATE) IS A MEDIATOR OF THE STRINGENT RESPONSE THAT COORDINATES A VARIETY OF CELLULAR ACTIVITIES IN RESPONSE TO CHANGES IN NUTRITIONAL ABUNDANCE. THIS ENZYME CATALYZES THE FORMATION OF PPPGPP WHICH IS THEN HYDROLYSED TO FORM PPGPP [CATALYTIC ACTIVITY: ATP + GTP = AMP + GUANOSINE 3'-DIPHOSPHATE 5-'TRIPHOSPHATE]. |
| Product | PROBABLE GTP PYROPHOSPHOKINASE RELA (ATP:GTP 3'- PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASE I) ((P)PPGPP SYNTHETASE) (GTP DIPHOSPHOKINASE) |
| Comments | ML0491, len: 787 aa. Probable relA, GTP pyrophosphokinase (EC 2.7.6.5), highly similar to RELA_MYCTU|Q50638|Rv2583c Probable relA, GTP pyrophosphokinase from M. tuberculosis (790 aa), Fasta scores: E(): 0, (93.4% identity in 790 aa overlap). Also similar to others e.g. O87331|RELA_CORGL|RELA|REL from Corynebacterium glutamicum (Brevibacterium flavum) (760 aa), FASTA scores: E(): 6.1e-209, (66.0% identity in 756 aa overlap). Previously sequenced as RELA_MYCLE|Q49640 (787 aa), Fasta scores: E(): 0, (99.9% identity in 787 aa overlap). Contains a probable helix-turn-helix motif at aa 41-62 (Score 1005, SD +2.61) Contains Pfam match to entry PF01842 ACT, ACT domain. Belongs to the RelA/SpoT family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 595608 | 597971 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0491|relA
VADDQGTAQALQPVQVVPGPAVEAPETPVETLKTSSSASRRVRARLARRMTAQRSTISPVLEPLVAVHKEFYPKANLSIVQRAFEVADQRHASQLRRSGDPYITHPLAVANILAELGMDITTLVAALLHDTVEDTGYTLEALSEEFGDEVGHLVDGVTKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIISTLGASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAAEPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEFVEIFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALEAGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYIDVSALYTAIGEGHVSARHVVQRLLAELGGIDQAEEELAERSTPTTMLRRQRSTDDVGVSVPGAPGVLTKLAKCCTPVPGDAIMGFVTRGGGVSVHRTDCTNTASLQQQAERIIEVLWAPSSSSVFLVAIQVEALDRHRLLLDITRALADERVDILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVMSAS
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