Gene ML0501 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameaspS
Gene length1770 bp
IdentifierML0501
Location 606840 bp
Protein summary information
Molecular mass64598.8 Da
Isoelectric point4.89
Protein length590 amino acids
Structural information
PFAMPF00152, PF01336, PF02938
Orthologs
M. tuberculosis H37RvRv2572c
M. lepromatosis Mx1-22AMLPM_0501
Cross-references
UniProtP36429
Gene OntologyAspartate-trna ligase activity, Aspartyl-trna aminoacylation, Cytoplasm, Nucleic acid binding, Atp binding
Enzyme Classification6.1.1.12
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (AspRS) (aspartic acid translase)
CommentsML0501, len: 589 aa. Probable aspS, aspartyl-tRNA synthetase (EC 6.1.1.12), highly similar to SYD_MYCTU|Q50649|Rv2572c aspS, aspartyl-tRNA synthetase from M. tuberculosis (596 aa), Fasta scores: E(): 0, (88.0% identity in 592 aa overlap); and CAD94787|Mb2602c from M. bovis (611 aa). And highly similar to many e.g. Q8FT19 Putative aspartyl-tRNA synthetase from Corynebacterium efficiens (617 aa), fasta scores: E(): 3.8e-190, (71.549% identity in 594 aa overlap); and SYD_ECOLI|P21889 aspS, aspartyl-tRNA synthetase from Escherichia coli (590 aa), Fasta scores: (46.8% identity in 583 aa overlap). Previously sequenced as SYD_MYCLE|P36429 (589 aa), Fasta scores: E(): 0, (99.8% identity in 589 aa overlap). Contains Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to the class-II aminoacyl-tRNA synthetase family.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS606840608609+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0501|aspS
VLRSHGAGVLRKSDAGQQVTLAGWVSRRRDHGGVIFIDLRDSSGITQAVFREPDVLAQAHRLRAEFCIAVSGVVEIRPEGNANAEIPTGDIEVNATSLTVLGESAPLPFQLDEPAGEELRLKYRYLDLRRDGPGSAIRLRSKVNATARAVLARHDFVEIETPTITRSTPEGARDFLVPARLRPGTFYALPQSPQLFKQLLMVAGMERYYQIAHCYRDEDFRADRQPEFTQLDMEMSFVDAEDVIAISEEILTELWMLIGYHIPAPIPRISYADAMRRFGSDKPDLRFGLELVECTEFFCDTTFRVFQAPYVGAVVMPGGAAQPRRTLDEWQDWAKQRGHRGLAYVLVTDDGTLGGPVAKNFSDAERSRLASHVGAEPGDCIFFSAGPAKSSRALLGAARGEIANRLGLIDPEAWAFVWVVDPPLFERADEATKVGEMAVGSGAWTAVHHAFTSPKPEFEDSIESDPGSVLADAYDIVCNGHEIGSGSVRINRRDIQERVFAVMGLEKAEAEEKFGFLLEAFTFGAPPHGGIAFGWDRTNALLAGMESIREVIAFPKTGGGVDPLTDAPASITAQQRKESGIDTKPKEVE
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