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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductProbable conserved membrane protein
CommentsML0514, len: 421 aa. Probable conserved membrane protein, highly similar to P95000|AL123456|Rv2553c Conserved membrane protein from M. tuberculosis (417 aa), Fasta scores: E(): 1.1e-123, (72.7% identity in 414 aa overlap); and CAD94768|Mb2583c from M. bovis (417 aa). C-terminal half is similar to e.g. Q9L9G6|AF170880 novB, gene from novobiocin biosynthetic gene cluster from Streptomyces sphaeroides (284 aa), Fasta scores: E(): 2.5e-22, (40.0% identity in 210 aa overlap). Shows full-length similarity to other hypothetical proteins e.g. Q9EWY3|2SCG38.36 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (253 aa), FASTA scores: E(): 1.1e-20, (38.835% identity in 206 aa overlap). Contains hydrophobic, possible membrane-spanning region near the N-terminus.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS625434626699+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0514|ML0514
MGDSYLARHRLAPEAAGLGRHQMSSGDRDGRRLAKSGYRCRRFADKIVFGLLVVVVVLATFVGLRLWHTLFGSADGYTDYAGAGKHDIMIQIHAGDSTTVIGETLRNQGVVASVRAFVDASHGNAAISSIQPGFYRMRTEIPAAAAAARLADPENRVGKLVIPEGRQLDDATDMTTGKVNPGIFSLISRATCVDLDGNRHCVSLNDLRAATRRTSLAKLSVPAWATESVIELGNDHRRIEGLIAPGTFNVDPSASADSIMANLISTSAVGYTDSGLVDTARSLGLSPYAILVVASLVQQEASPQDFPKVARVIYNRLYEHRTLEFDSTVNYPLDRREVATSDADRGLWTPWNTYVSPGLPATAICSPGIDALYAAEHPEPGDWLYFVTVDTQGTTLFTRDYQQHLTNIELAKHNGVLDSVR
      
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