Gene ML0515
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase) |
| Comments | ML0515, len: 278 aa. Probable aroE, shikimate 5-dehydrogenase (EC 1.1.1.25), highly similar to P95001|AL123456|Rv2552c aroE, shikimate 5-dehydrogenase from M. tuberculosis (269 aa), Fasta scores: E(): 0, (81.5% identity in 270 aa overlap); and CAD94767|Mb2582c from M. bovis (260 aa). Also highly similar, but longer than Q9KH59 Putative shikimate dehydrogenase (fragment) from Mycobacterium marinum (148 aa), FASTA scores: E(): 5.7e-38, (72.848% identity in 151 aa overlap); and Q9F7W3|AROE_METTH from Mycobacterium ulcerans (148 aa). Similar to many e.g. Q9KXQ2|AROE from Streptomyces coelicolor (255 aa), FASTA scores: E(): 1.7e-27, (41.339% identity in 254 aa overlap). Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. Belongs to the shikimate dehydrogenase family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 626677 | 627513 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0515|aroE
VSLTACANKGPRKAGIIGSPIAHSRSPHLHLAAYRALRLHDWTYERIECDAEELPTVVSGFGPQWVGVSVTMPGKFAALRFADEHTARASLVGSANTLLRTQRGWRADNTDIDGVAGALAAIGPLAGRALVCGSGGTAPAAVMGLAELGVTDITVLARNPDKASRLVDLGVQVGVATRLCGLDSGGLADEVKAAEVLVSTVPADVAARYVDVFATVPVLLDAIYDPWPTPLVAAVSAAGGRVISGLQMLLHQAFAQVEQFTGMPAPREAMACALAGLH
Bibliography
No article yet recorded
