Gene ML0519 (aroQ)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED AT THE THIRD STEP IN THE BIOSYNTHESIS OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO ACIDS (THE SHIKIMATE PATHWAY). CATALYZE A TRANS-DEHYDRATION VIA AN ENOLATE INTERMEDIATE [CATALYTIC ACTIVITY: 3-DEHYDROQUINATE = 3-DEHYDROSHIKIMATE + H(2)O]. |
| Product | 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) |
| Comments | ML0519, len: 145 aa. aroD, 3-dehydroquinate dehydratase (EC 4.2.1.10), highly similar to AROQ_MYCTU|P36918|Rv2537c aroD, 3-dehydroquinate dehydratase from M. tuberculosis (146 aa), Fasta scores: E(): 0, (85.9% identity in 142 aa overlap); and CAD94751|Mb2566c from M. bovis (147 aa). Similar to many e.g. AROQ_CORPS|P96750 aroQ, 3-dehydroquinate dehydratase from Corynebacterium pseudotuberculosis (146 aa), Fasta scores: E(): 6.7e-33, (61.0% identity in 136 aa overlap). Contains Pfam match to entry PF01220 DHquinase_II, Dehydroquinase class II. Contains PS01029 Dehydroquinase class II signature. Belongs to the type-II 3-dehydroquinase family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 630654 | 631091 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0519|aroD
MTMVNIINGPNLGRLGRREPDVYGSTTHEQLSALIERAAVEFGIKAVVRQSDSESQLLDWIHLAADAGEPVILNAGGLTHTSVALRDACAELSAPFIEVHISNVHAREEFRRHSYLSPLATGVITGLGVQGYLLALRYLAEIAGN
Bibliography
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