Gene ML0552
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | MODIFIES THE FREE AMINO GROUP OF THE AMINOACYL MOIETY OF METHIONYL-TRNA(FMET). THE FORMYL GROUP APPEARS TO PLAY A DUAL ROLE IN THE INITIATOR IDENTITY OF N-FORMYLMETHIONYL-TRNA BY:(I) PROMOTING ITS RECOGNITION BY IF2 AND (II) IMPAIRING ITS BINDING TO EFTU-GTP. [CATALYTIC ACTIVITY : 10-FORMYLTETRAHYDROFOLATE + L-METHIONYL-TRNA + H(2)O = TETRAHYDROFOLATE + N-FORMYLMETHIONYL-TRNA] |
| Product | Probable methionyl-tRNA formyltransferase Fmt |
| Comments | ML0552, len: 318 aa. Probable fmt, methionyl-tRNA formyltransferase (EC 2.1.2.9), highly similar to FMT_MYCTU|P71674|Rv1406 Probable fmt, methionyl-tRNA formyltransferase from M. tuberculosis (312 aa), Fasta scores: E(): 0, (81.0% identity in 316 aa overlap). Similar to many e.g. Q9L0Y6|FMT_STRCO Methionyl-tRNA formyltransferase from Streptomyces coelicolor (310 aa), fasta scores: E(): 4.7e-63, (57.962% identity in 314 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. Belongs to the Fmt family. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 669004 | 669960 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0552|fmt
VLVRLVFAGTPESALPALCRLIDSPRHDVIAVLTRPDAASGRRGKPEPSPVAREALDRGIPLLRPARPNSPVFVSELSEWAPECCVVVAYGALLGSPLLAVPPRGWVNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPVYGVVTETIQPTDTAGDLLERLAVSGATLLSSTLDGIADAILTPRQQPVDGVSFAPKITVEQARVCWDLPAPVVERRIRAVTPNPGAWTLVGKLRVKLGPVRFDSGAVEVPRLLKPLLPGGIHVDHKSVWIGTGSDPVRLSKVQPQGKKFMNAVDWAHGARLDPAARAS
Bibliography
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