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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionMODIFIES THE FREE AMINO GROUP OF THE AMINOACYL MOIETY OF METHIONYL-TRNA(FMET). THE FORMYL GROUP APPEARS TO PLAY A DUAL ROLE IN THE INITIATOR IDENTITY OF N-FORMYLMETHIONYL-TRNA BY:(I) PROMOTING ITS RECOGNITION BY IF2 AND (II) IMPAIRING ITS BINDING TO EFTU-GTP. [CATALYTIC ACTIVITY : 10-FORMYLTETRAHYDROFOLATE + L-METHIONYL-TRNA + H(2)O = TETRAHYDROFOLATE + N-FORMYLMETHIONYL-TRNA]
ProductProbable methionyl-tRNA formyltransferase Fmt
CommentsML0552, len: 318 aa. Probable fmt, methionyl-tRNA formyltransferase (EC 2.1.2.9), highly similar to FMT_MYCTU|P71674|Rv1406 Probable fmt, methionyl-tRNA formyltransferase from M. tuberculosis (312 aa), Fasta scores: E(): 0, (81.0% identity in 316 aa overlap). Similar to many e.g. Q9L0Y6|FMT_STRCO Methionyl-tRNA formyltransferase from Streptomyces coelicolor (310 aa), fasta scores: E(): 4.7e-63, (57.962% identity in 314 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. Belongs to the Fmt family.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS669004669960+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0552|fmt
VLVRLVFAGTPESALPALCRLIDSPRHDVIAVLTRPDAASGRRGKPEPSPVAREALDRGIPLLRPARPNSPVFVSELSEWAPECCVVVAYGALLGSPLLAVPPRGWVNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPVYGVVTETIQPTDTAGDLLERLAVSGATLLSSTLDGIADAILTPRQQPVDGVSFAPKITVEQARVCWDLPAPVVERRIRAVTPNPGAWTLVGKLRVKLGPVRFDSGAVEVPRLLKPLLPGGIHVDHKSVWIGTGSDPVRLSKVQPQGKKFMNAVDWAHGARLDPAARAS
      
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