Gene ML0624
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable heat-inducible transcription repressor HrcA |
| Comments | ML0624, len: 343 aa. Probable hrcA, heat-inducible transcriptional repressor (see citation below), highly similar to HRCA_MYCTU|O05824|Rv2374c hrcA, heat-inducible transcription repressor from M. tuberculosis (343 aa), Fasta scores: E(): 1.2e-116, (89.5% identity in 343 aa overlap); and CAD97256|Mb2395c from M. bovis (343 aa). Similar to many e.g. HRCA_BACST|Q45550 hcrA, heat-inducible transcription repressor from Bacillus stearothermophilus (344 aa), Fasta scores: E(): 3.5e-26, (28.3% identity in 336 aa overlap). Previously sequenced as Q49749|U00016 (197 aa), Fasta scores: E(): 0, (99.5% identity in 196 aa overlap). Contains Pfam match to entry PF01628 HrcA, HrcA protein. Belongs to the HrcA family. |
| Functional category | Virulence, detoxification, adaptation |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 756771 | 757802 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0624|hrcA
VGNADERRFEVLRAIVADFVATKEPIGSRALVERHNLGVSSATIRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLEDVKPLSAAERRAIQSFLESGVDLDDVLRRAVRLLAQLTCQVAVVQYPTLSTSTVRHLEVIALSPARLLMVVITESGRVDQRIAELGDVIDDYQLSQLREMLSQAMGGKKLSAASAAVADLVGRFRGTGGLANAVGRSANVLLESLVEHTEERLLLGGTANLTRNSADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETAAEQIMGTSMVSTAYGTSGTVYGGMGVLGPTRMDYPGTIASVAAVALYIGEVLGAR
Bibliography
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