Gene ML0625 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namednaJ2
Gene length1137 bp
IdentifierML0625
Location 757874 bp
Protein summary information
Molecular mass40367.5 Da
Isoelectric point6.06
Protein length379 amino acids
Structural information
PFAMPF00226, PF00684, PF01556
Orthologs
M. tuberculosis H37RvRv2373c
M. lepromatosis Mx1-22AMLPM_0625
Cross-references
UniProtQ49762
Gene OntologyCytoplasm, Heat shock protein binding, Protein folding, Response to stress, Unfolded protein binding, Zinc ion binding, Dna replication
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable chaperone protein DnaJ2
CommentsML0625, len: 378 aa. Probable dnaJ2, chaperone protein, highly similar to O05825|AL123456|Rv2373c Probable dnaJ2, chaperone protein from M. tuberculosis (382 aa), Fasta scores: E(): 1.7e-138, (88.0% identity in 382 aa overlap); and CAD97255|Mb2394c from M. bovis (382 aa). Similar to many e.g. Q9RDD7|DNJ2_STRCO Chaperone protein dnaJ2 from Streptomyces coelicolor (378 aa), fasta scores: E(): 1.2e-83, (54.068% identity in 381 aa overlap); and DNAJ_ECOLI|P08622 dnaJ, Dna protein from Escherichia coli (375 aa), Fasta scores: (40.6% identity in 382 aa overlap). Also similar to ML2494. Previously sequenced as Q49762|U00016 (378 aa), Fasta scores: E(): 0, (99.7% identity in 378 aa overlap). Contains Pfam match to entry PF01556 DnaJ_C, DnaJ C terminal region. Contains Pfam match to entry PF00684 DnaJ_CXXCXGXG, DnaJ central domain (4 repeats). Contains Pfam match to entry PF00226 DnaJ, DnaJ domain. Belongs to the DNAJ family.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS757874759010+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0625|dnaJ2
VARDYYGLLGVSRNASDADIKRAYRKLARELHPDINPDEAAQAKFKEISMAYEVLSDPEKRRIVDLGGDPMENAAASPSGFGGFGGLGDVFEAFFGGSSASRGPIGRVRPGSDSLLPMWLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSAPIPCDTCGGRGEVQTVQRSLLGQMVTARPCPTCRGVGVVIPDPCCQCVGDGRVRARREITVKIPSGVGDGMRVRLAAQGEVGPGGGPAGDLYVEVHEQAHDIFVRDGDDLHCTVSVPMVDAALGTTITVDAILDGMSEIDISPGTQPGSVIELRGQGMPHLRSNTRGNLHVHVEVMVPTRLDQHDTELLRELKRRRSRDVAEVRSTHAAGGGLFSRLRETFTNR
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