Gene ML0637
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN NUCLEOTIDE EXCISION REPAIR. HAS BOTH ATPASE AND HELICASE ACTIVITIES. UNWINDS DNA DUPLEXES WITH 3' TO 5' POLARITY WITH RESPECT TO THE BOUND STRAND AND INITIATES UNWINDING MOST EFFECTIVELY WHEN A SINGLE-STRANDED REGION IS PRESENT. INVOLVED IN THE POSTINCISION EVENTS OF NUCLEOTIDE EXCISION REPAIR AND METHYL-DIRECTED MISMATCH REPAIR. |
| Product | Probable ATP-dependent DNA helicase II UvrD2 |
| Comments | ML0637, len: 717 aa. Probable uvrD2, ATP dependent DNA helicase II (EC 3.6.1.-), highly similar to UVRD_MYCTU|O53344|Rv3198c uvrD2, probable ATP-dependent DNA helicase II from M. tuberculosis (700 aa), Fasta scores: E(): 0, (82.9% identity in 706 aa overlap); and CAD95314|Mb3222c (700 aa) from M. bovis. Similar to many e.g. UVRD_ECOLI|P03018 uvrD, DNA helicase II from Escherichia coli (720 aa), Fasta scores: E(): 1.1e-20, (32.6% identity in 660 aa overlap). And similar to ML0153|uvrD1. Previously sequenced as UVRD_MYCLE|P53528 (457 aa), Fasta scores: E(): 0, (100.0% identity in 439 aa overlap). Contains Pfam match to entry PF00570 HRDC, HRDC domain. Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 769119 | 771272 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0637|uvrD2
MDPMVMVVNPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAHLVGAGHVATGQVLAVTFTQRAAAEMRSRLRALGAAVQAVSDFGVVRVLTFHAAAHRQLRYFWPRVIGDTGWQLLDSKFATVARAASSVRLHAGTDDVCDLAGEIEWAKASLIGPEEYVAAVAAIGRDTPLDAAQIASVYAAYEALKARGNGVPGVTLLDFDDLLLHTAAAIENDAAVAEEFRDRYRCFVVDEYQDVTPLQQRVLSAWLGDRDDLTVVGDANQTIYSFTGASPCFLLDFPRRFPDATVVRLERDYRSTPQVVSLANQVIAAAHGRVADSKFQLSGQREPGPAASFHEYSDEPAEAAAVAASIARLIEFGTSPSEIAVLYRVNAQSEAYEEALTEVGIAYQVRGGEGFFNRQEIKQALLALQRSAERSSQTEPNSPLSDVVRGVLEPLGLTAEKPVGSRARDRWEALTALAELADDEVAQHPRLDLPGLLAELRLRADARHPPVVQGVTLASLHAVKGLEWDAVFLVGLADGTLPISRALAHGAESEPVEEERRLLYVGITRARVYLALSWALSRTPGGRQSRKPSRFLNDIAPQMGQNPASSRSRRNRTATLRCRICKNDLTTPAAVMLQRCQICAADVDEELLLQLKAWRLSTAKEQNVPAYVVLTDNTLIAIAELLPADEAALIAVPGMSVRKIEQYGSDVLQLVRCRAVAVRTQT
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