Gene ML0661c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadE24
Gene length1398 bp
IdentifierML0661c
Location 797293 bp
Protein summary information
Molecular mass49832.9 Da
Isoelectric point7.59
Protein length466 amino acids
Structural information
PFAMPF00441, PF02770, PF02771
Orthologs
M. tuberculosis H37RvRv3139
M. lepromatosis Mx1-22AMLPM_0661
Cross-references
UniProtO32890
Gene OntologyAcyl-coa dehydrogenase activity, Electron carrier activity, Metabolic process, Flavin adenine dinucleotide binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable acyl-CoA dehydrogenase FadE24
CommentsML0661c, len: 465 aa. Probable fadE24, acyl-CoA dehydrogenase (1.3.99.-), highly similar to P95187|AL123456|Rv3139 fadE24, acyl-CoA dehydrogenase from M. tuberculosis (468 aa), Fasta scores: E(): 2e-163, (83.6% identity in 464 aa overlap); and CAD95255|Mb3163 from M. bovis (468 aa). Similar to many e.g. Q9HUH0 Probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (429 aa), fasta scores: opt: 1116, E(): 5.2e-66, (44.836% identity in 426 aa overlap). Also similar to ML0737. Previously sequenced as O32890|Z98271 (465 aa), Fasta scores: E(): 0, (100.0% identity in 465 aa overlap) .Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehydrogenases signature 2.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS797293798690-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0661c|fadE24
MTDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFLDKYHLRYPLNRALRYGVKATFSTAAATSRQFKRVQNLRGGATRLQPSGRNYFDLTPDDNQKLIVETIDEFSAEILRPAAHDADEAAAYPPDLIAKAAKLGITTINIPEYFDGIAERRSSVTNVLVAEALAYGDMGLTLPILAPGGVAATLTYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRLKTIAVRTPSGYRLDGVKSLVPAAASAELFIIGAQLNGKPALFIVESSTKGLTVKADPSMGIRAAALGQVELCGVSAPLDARLGEDDATDNDYSEAIALARLGWAALAVGTSHAVLDYVMPYVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRGASRAEQGLSFAREAALAKRLGSDKAMQIGLDGVQLLGGHGFIKEHPVERWYRDLRAIGVAEGVVVI
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