Gene ML0696c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable succinate dehydrogenase (iron-sulfur protein subunit) SdhB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) |
| Comments | ML0696c, len: 264 aa. Probable sdhB, iron-sulphur protein succinate dehydrogenase SdhB subunit (EC 1.3.99.1), highly similar to O53371|AL123456|Rv3319 sdhB, iron-sulphur protein succinate dehydrogenase from M. tuberculosis (263 aa), Fasta scores: E(): 0, (89.8% identity in 264 aa overlap); and CAD95442| from M. bovis (263 aa). Similar to many e.g. DHSB_ECOLI|P07014 sdhB, succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa), Fasta scores: E(): 0, (42.9% identity in 240 aa overlap). Previously sequenced as Q49916|U00022 (264 aa), Fasta scores: E(): 0, (100.0% identity in 264 aa overlap). Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. COFACTOR: BINDS THREE DIFFERENT IRON-SULFUR CLUSTERS: A 2FE-2S, A 3FE-4S AND A 4FE-4S. THE IRON-SULFUR CENTERS ARE SIMILAR TO THOSE OF 'PLANT-TYPE' 2FE-2S AND 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 833873 | 834667 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0696c|sdhB
MAVEPVEVKSLEPPRPPISDDAVMVTVKIARFNPDNPDAFAETGGWQSFRVPCLPTDRLLNLLIYIKGYLDGTLTFRRSCAHGVCGSDAMRVNGVNRLACKVLMRDLLPKKAGKNLTITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITSGNPPTRERIQSPTDRARYDDTTKCILCACCTTSCPVFWSEGTYYGPAAIVNAHRFIFDSRDEGAGERLTLLNEVDGVWRCRTTFNCTESCPRNIEVTKAIQEVKRALMFSR
Bibliography
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