Gene ML0728c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) |
| Comments | ML0728c, len: 296 aa. Probable sseA, thiosulfate sulfurtransferase (EC 2.8.1.1), highly similar to THT2_MYCTU|P96888|Rv3283 sseA, thiosulfate sulfurtransferase from M. tuberculosis (297 aa), Fasta scores: E(): 5.4e-110, (83.4% identity in 296 aa overlap); and CAD95403|Mb3311 from M. bovis (297 aa). Similar to many e.g. P71121|THTR_CORGL Thiosulfate sulfurtransferase from Corynebacterium glutamicum (Brevibacterium flavum) (301 aa), fasta scores: E(): 1.5e-73, (58.276% identity in 290 aa overlap). Also similar to ML2198 from M. leprae and Rv3117 from M. tuberculosis. Previously sequenced as THT2_MYCLE|P46700 (296 aa), Fasta scores: E(): 0, (99.7% identity in 296 aa overlap). Contains 2 Pfam matches to entry PF00581 Rhodanese, Rhodanese-like domain. Contains PS00380 Rhodanese signature 1. Contains PS00683 Rhodanese C-terminal signature. BELONGS TO THE RHODANESE FAMILY. In M. tuberculosis sseA is thought to be differentially expressed within host cells (see Triccas et al., 1999). |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 870029 | 870919 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0728c|sseA
VPLPTDPSPSLSAYAHPERLVTGDWLYFHLGKPGLAIVESDENVLLYDVGHIPGAVKVDWHTDLNDPKVRDYITGEQFADLMNRKGIARDDTVVIYGDKSNWWAAYALWVFTLFGHPDVRLLNGGRDLWLAERRDTSLAVPNKTSTSYPVVNRNDAPIRAFKDDVLAILGTQPLIDVRSLDEYTGKCTEMPDSPEESVLRAGHIPTARSIPWEMTVDKSGRFRSSEELERLYDFITPNDKTIVYCRIGERSSHTWFVLTHLLGKPGVRNYDGSWTEWGNTVRVPITAGESPGAVPV
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