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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionBIRA ACTS BOTH AS A BIOTIN-OPERON REPRESSOR AND AS THE ENZYME THAT SYNTHESIZES THE COREPRESSOR, ACETYL-COA:CARBON-DIOXIDE LIGASE. THIS PROTEIN ALSO ACTIVATES BIOTIN TO FORM BIOTINYL-5'-ADENYLATE AND TRANSFERS THE BIOTIN MOIETY TO BIOTIN-ACCEPTING PROTEINS [CATALYTIC ACTIVITY: ATP + BIOTIN + APO-[ACETYL-COA:CARBON-DIOXIDE LIGASE (ADP FORMING)] = AMP + PYROPHOSPHATE + [ACETYL-COA:CARBON-DIOXIDE LIGASE (ADP FORMING)]]
ProductPOSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGASE)
CommentsML0732, len: 274 aa. Possible birA, bifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15), highly similar to P96884|Z92771|Rv3279c|MTCY71.19c birA, bifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase from Mycobacterium tuberculosis (266 aa), fasta scores: E(): 1.5e-69, (71.2% identity in 271 aa), and CAD95399| from M. bovis (266 aa). Similar to others e.g. P42975|BIRA_BACSU BirA bifunctional protein [Includ (325 aa), fasta scores: E(): 2.2e-12, (31.321% identity in 265 aa overlap). Lacks the N-terminal helix-turn-helix domain, so may not act as a repressor. Contains Pfam match to entry PF01317 BPL, Biotin protein ligase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS873721874545+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0732|birA
LGSDLLKPPLDPAALRAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGILAEVVRPVIVVGVGLNVTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQTVVISAGDVVHLR
      
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