Gene ML0736
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN PURINE BIOSYNTHESIS (SIXTH STEP). THIS SUBUNIT CAN ALONE TRANSFORM AIR TO CAIR, BUT IN ASSOCIATION WITH PURK, WHICH POSSESSES AN ATPASE ACTIVITY, AN ENZYME COMPLEX IS PRODUCED WHICH IS CAPABLE OF CONVERTING AIR TO CAIR EFFICIENTLY UNDER PHYSIOLOGICAL CONDITION [CATALYTIC ACTIVITY: 1-(5-PHOSPHORIBOSYL)-5-AMINO-4-IMIDAZOLE-CARBOXYLATE = 1-(5-PHOSPHORIBOSYL)-5-AMINOIMIDAZOLE + CO(2)]. |
| Product | Probable phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (AIR CARBOXYLASE) (AIRC) |
| Comments | ML0736, len: 171 aa. Probable purE, phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21), highly similar to Rv3275c|MTCY71.15c|PUR6_MYCTU|P96880 purE, phosphoribosylaminoimidazole carboxylase catalytic subunit from Mycobacterium tuberculosis (174 aa), fasta scores: E(): 2.9e-49, (81.5% identity in 168 aa) and CAD95395| from M. bovis (174 aa). Similar to several e.g. PUR6_CORAM|Q44679 phosphoribosylaminoimidazole carboxylase catalytic subunit from Corynebacterium ammoniagenes (177 aa), fasta scores: E(): 1.1e-33, (66.2% identity in 148 aa). Previously sequenced as PUR6_MYCLE|P46702. Contains Pfam match to entry PF00731 AIRC, AIR carboxylase. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 877244 | 877759 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0736|purE
MTRQPRVGVIMGSDSDWSVMQDAAHALAEFDIPIEVRVVSAHRTPAEMFDYARNAVDRSIAVIIAGAGGAAHLPGMVASATPLPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILGSSDLQLRAQLVAFQDRLADTVRAKDADLQRFRGKLIGD
Bibliography
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