Gene ML0751 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namermlD
Gene length936 bp
IdentifierML0751
Location 893622 bp
Protein summary information
Molecular mass32099.9 Da
Isoelectric point5.39
Protein length312 amino acids
Structural information
PFAMPF04321
Orthologues
M. tuberculosisRv3266c
Cross-references
UniProtQ9CCK8
Gene OntologyDtdp-4-dehydrorhamnose reductase activity, Extracellular polysaccharide biosynthetic process, Binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductdTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-RHAMNOSE MODIFICATION PROTEIN) (dTDP-RHAMNOSE BIOSYNTHESIS PROTEIN) (dTDP-RHAMNOSE SYNTHASE)
CommentsML0751, len: 311 aa. Probable rmlD, dTDP-6-deoxy-L-lyxo-4-hexulose reductase (dTDP-rhamnose modification protein) (EC 1.-.-.-) (see citations below), highly similar to Rv3266c|MTCY71.06c|P96871|Z92771 rmlD, dTDP-6-deoxy-L-lyxo-4-hexulose reductase from Mycobacterium tuberculosis (304 aa), fasta scores: E(): 0, (74.4% identity in 312 aa); and CAD95386|Mb3294c from M. bovis (304 aa). Similar to several dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) e.g. P29781|STRL_STRGR dTDP-4-dehydrorhamnose reductase from Streptomyces griseus (304 aa), fasta scores: E(): 1.4e-32, (44.409% identity in 313 aa overlap).
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS893622894557+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0751|rmlD
VSDRSGRLVITGAGGQLGSALAAQATAAGRDVLALTSSQWDITDAAVAERMGRSALKKNDVVVNCAAYTNVDGAESNELAAYAVNATGPEYIARACRCAGAALIHVSTDYVFSGDFGSGANRVAPRPYEPTDETGPLGVYGRSKLAGEQAVLAAMPEATVVRTAWVYTGGTGKDFVAVMRRLAAGDGPVYVVDDQIGSPTYVVDLAAALLQVADGSVHGSVLHAANEGEVSRFGQARAVFEECGADPLQVQPVSTAQNPRSAARPAYSALSGRQSVAAGLTPLRPWRSALVEALAVSRSLPVDRPLPSTRD
Bibliography
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