Gene ML0752
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE WbbL1 (ALPHA-L-RHAMNOSE-(1->3)-ALPHA-D-GlcNAc(1->P)-P-DECAPRENYL) |
| Comments | ML0752, len: 308 aa. Probable wbbL1, dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3-L-rhamnosyl transferase (EC 2.-.-.-) (see citations below), highly similar to Rv3265c|MTCY71.05c|P96870|Z92771 wbbL1, dTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL A-3-L-RHAMNOSYL TRANSFERASE from Mycobacterium tuberculosis (301 aa), fasta scores: E(): 3.4e-110, (84.7% identity in 301 aa), and to Q9RN50|AF187550 (see note * below) dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol from Mycobacterium smegmatis (296 aa), fasta scores: E(): 5.5e-89, (69.9% identity in 296 aa). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. [* Note: UNPUBLISHED (experimental study on Mycobacterium smegmatis). Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan linker formation enzyme, dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase is essential for mycobacterial viability - Mills J.A., Motichka K., Jucker M., Wu H.P., Uhlic B.C., Stern R.J., Scherman M.S., Vissa V.D., Yan W., Pan F., Kimbrel S., Kundu M., McNeil M.]. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 894550 | 895476 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0752|wbbL
VTDVLPVVAVTYSPGPHLERFLASLALATDRPVSVVLADNGSTDGTPQVAVERYVNVRLFETGANLGYGTAANLAIAQFFEEGGATGQPWVDDWVIVANPDVQWGPGSIDALLDAAARWPRAGALGPLIRDPDGSVYPSARHLPSLVRGGMHAVLGPVWPRNPWTAAYRQERLELTERPVGWLSGSCLLVRRSAFREVGGFDERYFMYMEDVDLGDRLGKAGWLSVYVPSAEVLHHKGHSTGRDPVSHLAAHHKSTYIFLADRHSGWWRAPLRWMLRGSLVVRSRLMVRSSRRKQAAKQARQLAEGRR
Bibliography
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