Gene ML0808c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | COULD BE INVOLVED IN ENTEROBACTIN BIOSYNTHESIS. ENTEROBACTIN IS AN IRON-CHELATING COMPOUND INVOLVED IN TRANSPORTING IRON FROM THE BACTERIAL ENVIRONMENT INTO THE CELL CYTOPLASM. COULD BE ALSO INVOLVED IN 2,3-DIHYDROXYBENZOATE OR ENTEROCHELIN OR MENAQUINONE BIOSYNTHESIS [CATALYTIC ACTIVITY: CHORISMATE = ISOCHORISMATE]. |
| Product | probable isochorismate synthase EntC |
| Comments | ML0808c, len: 577 aa. Probable entC, isochorismate synthase (EC 5.4.99.6), highly similar to Rv3215|MTCY07D11.11c|O05851|Z95120 entC, isochorismate synthase from Mycobacterium tuberculosis (372 aa), fasta scores: E(): 0, (73.5% identity in 366 aa) and to Bacillus subtilis isochorismate synthase dhbC (398 aa) DHBC_BACSU|P45744 fasta scores: E(): 0, 37.9% identity in 396 aa. Also similar to ML0236 and ML1269 from M. leprae. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 956157 | 957890 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0808c|entC
MAIRRGRNRASTFGCTELELTDTGRAQAKLAERALAEQKLVDPMMASNPRQCDLVTAKLAGLTVDKVSPLLAECTYGSYEDLTTAKTREAEPAWLAWTHRYPRGEKRLASQRTCRPGRRYGVRALGVTDHVVRQPWPPLLGGDHTLDRAAICRGPALRYAHQLDWDVRVRVRATATTHAWVAWLATTGRTRVNINNDDDKRRPVAQERAEQMRPSEPPFALCGPRGTLVADGVHTRYDDVYLAQAALRSGVTPILLGALPFDAESPAALMAPSAVLRTDTLPNWQTGPLPTLRITAAVPTRANYRVWISNAREQLTAPGNSLHKVVLARALQLVADAPLDGRAILRRLVTADPTAYGYLVDLTAAGGQYAGVALVGASPELLVSRFGDRVVCRPFAGSAPRATNPEVDSANSAALAGSIKNRHEHQLVIDAIRAALEPVCDNLTIAPEPELSRTAAVWHLCTPISGRLRDTSITAIDLALMLHPTPAVGGVPAEAASELIAALEGDRGFYAGAVGWCDARGDGHWVVSIRCAQLSADRRIAFAHAGGGIVAESDPDDEVDETTAKFATILNALGVKQ
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