Gene ML0852 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameribF
Gene length996 bp
IdentifierML0852
Location 1012138 bp
Protein summary information
Molecular mass36154.2 Da
Isoelectric point6.65
Protein length332 amino acids
Structural information
PFAMPF01687, PF06574
Orthologs
M. tuberculosis H37RvRv2786c
M. lepromatosis Mx1-22AMLPM_0852
Cross-references
UniProtO32968
Gene OntologyRiboflavin biosynthetic process, Riboflavin kinase activity, Fmn adenylyltransferase activity
Enzyme Classification 2.7.7.2, 2.7.1.26
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE BIFUNCTIONAL FAD SYNTHETASE/RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBF: RIBOFLAVIN KINASE (FLAVOKINASE) + FMN ADENYLYLTRANSFERASE (FAD PYROPHOSPHORYLASE) (FAD SYNTHETASE)(FAD DIPHOSPHORYLASE) (FLAVIN ADENINE DINUCLEOTIDE SYNTHETASE)
CommentsML0852, len: 331 aa. Probable ribF, FAD synthetase/riboflavin biosynthesis protein, bifunctional enzyme (EC 2.7.1.26. Similar to Mycobacterium tuberculosis riboflavin kinase ribF or Rv2786c or MTV002.51C TR:O33328 (EMBL:AL008967) (331 aa) fasta scores: E(): 0, 87.5% identity in 327 aa and to many others e.g. Corynebacterium ammoniagenes riboflavin biosynthesis protein RibF (includes riboflavin kinase) ribF SW:RIBF_CORAM (Q59263) (338 aa) fasta scores: E(): 0, 47.7% identity in 321 aa. Previously sequenced as TR:O32968 (EMBL:Z98741). Contains Pfam match to entry PF01687 FAD_Synth, Riboflavin kinase / FAD synthetase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10121381013133+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0852|ribF
MGSRRLAIVQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHTELIAHTVQTGRARNVPTVLMTFDPHPMEVVYPGSHPAQLTTLTRRAELIEELGIDVFLVMPFTTDFMKLTPDRYVHELLVEHLHVVEVVVGENFTFGKKAAGNVIMLRRAGQRFGFAVGSMSLLSEHRGNETVAFSSTYIRSCVDAGDMMAATEALGRPHRVEGMVVRGQGRGTELGFPTANVASPMYSATPADGVYAAWFTVLGHGPVTGTVVPGECYQAAVSVGTNPTFSGRTRTVEAFVLDAVADLYGQHVALDFVGRIRGQRKFDSVADLVAEMEKDIDRARALLAD
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