Gene ML0855 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepepR
Gene length1275 bp
IdentifierML0855
Location 1016252 bp
Protein summary information
Molecular mass45956.2 Da
Isoelectric point6.46
Protein length425 amino acids
Structural information
PFAMPF00675, PF05193
Orthologues
M. tuberculosisRv2782c
Cross-references
UniProtO32965
Gene OntologyProteolysis, Zinc ion binding, Metalloendopeptidase activity
Enzyme Classification3.4.24.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ZINC PROTEASE PEPR
CommentsML0855, len: 424 aa. Probable pepR, protease/peptidase (EC 3.4.99.-). Similar to Mycobacterium tuberculosis hypothetical zinc protease Rv2782c or MTV002.47C SW:YR82_MYCTU (O33324) (438 aa) fasta scores: E(): 0, 84.3% identity in 421 aa and to others, both bacterial and eukaryotic e.g. Homo sapiens mitochondrial processing peptidase beta subunit precursor pmpcB or mppB SW:MPPB_HUMAN (O75439) (489 aa) fasta scores: E(): 0, 30.6% identity in 434 aa. Previously sequenced as SW:YR82_MYCLE (O32965). Contains Pfam match to entry PF00675 Peptidase_M16, Insulinase (Peptidase family M16). Contains PS00143 Insulinase family, zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M16, ALSO KNOWN AS THE INSULINASE FAMILY. COFACTOR: REQUIRES DIVALENT CATIONS FOR ACTIVITY. BINDS ZINC.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10162521017526+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0855|pepR
VCRTTLPGGLRVVTEHLPAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTSTRTAMDIAQAIDAVGGELNAFTAKEHTCYYAHVLDSDLELAVDLVADVVLNGRCAVDDVELERDVVLEEIAMRDDDPEDALGDMFLAALFGDHPVGRPVIGTMESVSAMTRTQLHSFHVRRYTPERMVVAVAGNVDHDEMVALVREHFGSRLIRGRQSAPPRKSTGRINGGPALTLGKRDAEQTHVLLGVRTPGRSWEHRWALSVLHTALGGGLSSRLFQEIRETRGLAYSVYSALDIFADSGALSVYAACLPGRFADVMQVISEVLASVAGDGITEAECRIAKGSLRGGIILGLEDSNSWMSRLGRSELNYGKYRGIEHTLQQIDEVTVEQVNALAHQLLNKRYGAAVLGPYASKKTLPRQLRIMVN
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