Gene ML0868c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in Cobalamin biosynthesis. Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). [Catalytic activity : Beta-nicotinate D-ribonucleotide + dimethylbenzimidazole = nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole. |
| Product | Probablenicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT |
| Comments | ML0868c, len: 351 aa. Probable cobT, nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase (EC 2.4.2.21). Similar to Mycobacterium tuberculosis putative nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT or Rv2207 or MTCY190.18 SW:COBT_MYCTU (Q10396) (361 aa) fasta scores: E(): 0, 81.4% identity in 355 aa. Similar to many e.g. Salmonella typhimurium nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT SW:COBT_SALTY (Q05603) (356 aa) fasta scores: E(): 5.9e-32, 34.1% identity in 340 aa. Previously sequenced as O32953 (EMBL:Z98741). Belongs to the cobT family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1032059 | 1033114 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0868c|cobT
MEFAPVSPPDGHAAAAARARQDTLTKPRGALGRLEDLSIWVASCQGQCPPRQFQRARIVVFAGDHGVARSGVSAYPPQLTAQMVANIDRGGAAINALASIADATIRIADLAVDADPLSQQIGIHKVRRGSGDIAIQDALTEDETARAIIAGQRIADEEVDRGADLLIAGDIGIGNTTAAAVLVAALTNAEPVAVVGFGTGIDDASWARKTAAVRDALCRIRLVLPDPVGLLRCCGGADLAAMAGFCAQAAVRRTPLLLDGMVVTAAALVAERLAPGSWQWWQAGHQSTEPGHALALAALDLDPILDLRMRLGEGTGATAALLVLRAAVAALTSMTTFAEAGVAGTSTSPPS
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