Gene ML0908 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepbpB
Gene length2028 bp
IdentifierML0908
Location 1073835 bp
Protein summary information
Molecular mass72389.3 Da
Isoelectric point9.59
Protein length676 amino acids
Structural information
PFAMPF00905, PF03717
Orthologs
M. tuberculosis H37RvRv2163c
M. lepromatosis Mx1-22AMLPM_0908
Cross-references
UniProtO69558
Gene OntologyPeptidoglycan-based cell wall biogenesis, Penicillin binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable penicillin-binding membrane protein PbpB
CommentsML0908, len: 675 aa. Probable pbpB, penicillin-binding membrane protein. Identical to the previously sequenced Mycobacterium leprae penicillin binding protein 2 TR:O69558 (EMBL:AL022602) (675 aa), Fasta scores: E(): 0, 99.9% identity in 675 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2163c TR:O06214 (EMBL:Z95388) (679 aa), Fasta scores: E(): 0, 80.6% identity in 677 aa overlap(EMBL:Z95388) and to many other penicillin-binding proteins e.g. Neisseria meningitidis SW:PBP2_NEIME (P11882) (581 aa), Fasta scores: E(): 4.3e-29, 32.4% identity in 590 aa overlap(P11882). Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10738351075862+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0908|pbpB
VRRGDAHRPCSSRSAQLGNSSSTPPVRQPKRLRQPEKARKAKDTKKSRSAVAADAVTEGRSARKRRTRQVVEIGTYGPSFIFRHRGGNVVIFALMLVAATQLFNLQVSNAAGLRAQAAGQLRVTDVEKAVRGSITDRNNEQLAFTIESRALTFQPKKIRQQLEEAKQKTPSAPDPQQRLQDIAKEVAGRLSNKPDGPSLLKKLQSNDSFVYLARAVDPAVAEAISAKYPEVGSERQDLRQYPGGSLAANIVGGIDWDGHGLLGLEDSLDSVLSGTDGSVTYDRGSDGVVIPGSYRNRHRAVNGSTVQLTIDDDIQFYVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGGKQLGNLAVSSPFEPGSVNKVITASAVIEYGLSTPDEVLQVPGSIQMGGVSVHDAWEHGVMPYTTTGVFGKSSNVGTLMLAQRVGPERFYDMVRKFGLGQLTGVGLPGESEGLVPSVDQWSGSTFSNLPIGQGLSTTLLQMTGMYQVIANDGVRIPPRIIKATNAADGTRTQEPRPDGIRVVSPQTAQTVRQMLRAVVQKDPMGYQQGTGPAAGVSGYQIAGKTGTAQQVNPACRCYFDDVYWITFAGMATVDNPRYVIGTMMDNPERNADGTPGHSAAPLFHNVAGWLMQRENVPLSPDPGPPLTLQAT
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