Gene ML0909 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemurE
Gene length1593 bp
IdentifierML0909
Location 1076004 bp
Protein summary information
Molecular mass54776.2 Da
Isoelectric point5.32
Protein length531 amino acids
Structural information
PFAMPF01225, PF02875, PF08245
Orthologs
M. tuberculosis H37RvRv2158c
M. lepromatosis Mx1-22AMLPM_0909
Cross-references
UniProtO69557
Gene OntologyUdp-n-acetylmuramoylalanyl-d-glutamate-2,6-diaminopimelate ligase activity, Cell cycle, Cell division, GO:0007047, Cytoplasm, Peptidoglycan biosynthetic process, Regulation of cell shape, Atp binding
Enzyme Classification6.3.2.13
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbableUDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE
CommentsML0909, len: 530 aa. Probable murE, UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase (EC 6.3.2.13). Identical to the previously sequenced Mycobacterium leprae UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) SW:MURE_MYCLE (AL022602) (530 aa), Fasta scores: E(): 0, 99.8% identity in 530 aa overlap. Also highly similar to MurE orthologues from Mycobacterium tuberculosis SW:MURE_MYCTU (O06219) (535 aa), Fasta scores: E(): 0, 74.4% identity in 519 aa overlap and Escherichia coli SW:MURE_ECOLI (P22188) (494 aa), Fasta scores: E(): 0, 39.1% identity in 493 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Belongs to the murCDEF family.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10760041077596+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0909|murE
VTEVVAVPVRLRPSATAGVRLPELVAQVGAVLADGPGQAATVPDIPVTGVTLRAQEVLSGDLFAALAGASTHGARYAGVALERGAVAVLTDVAGVAELTAQASSVPILIHPEPRSVLGGLAAAAYGHPSNRMTVVGITGTSGKTTTTYMVEAGLRAGGRVVGLVGTIGIRIDGADIPSFLTTPEAPALQAMLAAMVERGVETVVMEVSSHALSLGRVEGTQFAVAGFTNLSRDHLDFHPDMEEYFEAKAVLFDPHSLLRARTVVVCIDDDAGRATAARAGDAITVSALGQPASWRATDIRSPGVGAQEFTAVDPAGVQHRVGIRLPGRYNVANCLVALAILDVVGVSPEQASLGFRDIRIPGRLERIDCGQDFLALVDYAHKPGALHSVLTALLQPDHRLAVVFGAGGERDPGKRAPMGEIAAELADLVVVTDDNPRGEDPAAIRRDILTGTVAAGGAAQVVEIGDRRAAIQYAVAWAGPDDVVLVAGKGHETGQRGAAETCPFDDRVELARALQVRDARLLPAPGRACQ
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