Gene ML0912 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemurD
Gene length1473 bp
IdentifierML0912
Location 1080224 bp
Protein summary information
Molecular mass50550.8 Da
Isoelectric point5.64
Protein length491 amino acids
Structural information
PFAMPF02875, PF08245
Orthologs
M. tuberculosis H37RvRv2155c
M. lepromatosis Mx1-22AMLPM_0912
Cross-references
UniProtP57995
Gene OntologyUdp-n-acetylmuramoylalanine-d-glutamate ligase activity, Cell cycle, Cell division, GO:0007047, Cytoplasm, Peptidoglycan biosynthetic process, Regulation of cell shape, Atp binding
Enzyme Classification6.3.2.9
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD
CommentsML0912, len: 490 aa. Probable murD, UDP-N-acetylmuramoylalanine-D-glutamate ligase. Identical to the previously sequenced Mycobacterium leprae UDP-N-acetylmuramoylalanine-D-glutamate ligase TR:O69554 (EMBL:AL022602) (490 aa), Fasta scores: E(): 0, 99.8% identity in 490 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:MURD_MYCTU (SW:O06222) (486 aa), Fasta scores: E(): 0, 75.9% identity in 493 aa overlap and Bacillus subtilis SW:MURD_BACSU (SW:Q03522) (451 aa), Fasta scores: E(): 7.1e-24, 28.4% identity in 493 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Belongs to the murCDEF family.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10802241081696+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0912|murD
VLDTLVPGAPVLVAGGGVTGRAVLAALTRFGMAATLCDDDPAALQQYADNGVATVSAATATQQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVTGTNGKTTTTSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSGPVGVLDALAAAALARSVGVGATAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGGTIGTRVMVAAVAAARDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR
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