Gene ML0961c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | CATALYZES THE TRANSFER OF A METHYL GROUP FROM 5-METHYLTETRAHYDROFOLATE TO HOMOCYSTEINE RESULTING IN METHIONINE FORMATION (PATHWAY: TERMINAL STEP IN THE DE NOVO BIOSYNTHESIS OF METHIONINE) [CATALYTIC ACTIVITY : 5-METHYLTETRAHYDROPTEROYLTRI-L-GLUTAMATE + L- HOMOCYSTEINE = TETRAHYDROPTEROYLTRI-L-GLUTAMATE + L-METHIONINE.] |
| Product | PROBABLE5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE METE (methionine synthase, vitamin-B12 independent isozyme) |
| Comments | ML0961c, len: 760 aa. Probable metE, 5-methyltetrahydropteroyltriglutamate-homocystein methyltransferase (EC 2.1.1.14). Identical to the previously sequenced Mycobacterium leprae 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) SW:METE_MYCLE (O05564) (760 aa), Fasta scores: E(): 0, 100.0% identity in 760 aa overlap. Also highly similar to MetE orthologues from Mycobacterium tuberculosis Rv1133c SW:METE_MYCTU (O06584) (759 aa), Fasta scores: E(): 0, 85.0% identity in 759 aa overlap and Escherichia coli SW:METE_ECOLI (P25665) (752 aa), Fasta scores: E(): 0, 47.5% identity in 754 aa overlap. Contains Pfam match to entry PF01717 Methionine_synt, Methionine synthase, vitamin-B12 independent. BELONGS TO THE VITAMIN-B12 INDEPENDENT METHIONINE SYNTHASE FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1127780 | 1130062 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0961c|metE
MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDLESALSKLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDNLRSWLAFGAEKVAEVVVLARALRDGRDAVADEIAASNAAVASRRSDPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQVDEPALRELLPLRRADQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA
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