Gene ML0977 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameftsK
Gene length2661 bp
IdentifierML0977
Location 1144499 bp
Protein summary information
Molecular mass94895.7 Da
Isoelectric point6.8
Protein length887 amino acids
Structural information
PFAMPF01580, PF09397
Orthologs
M. tuberculosis H37RvRv2748c
M. lepromatosis Mx1-22AMLPM_0977
Cross-references
UniProtO05560
Gene OntologyDna binding, Cell cycle, Cell division, Chromosome segregation, Integral to membrane, Nucleoside-triphosphatase activity, Plasma membrane, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE CELL DIVISION TRANSMEMBRANE PROTEIN FTSK
CommentsML0977, len: 886 aa. Probable Cell division transmembrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05560 (EMBL:Z94723) (886 aa), Fasta scores: E(): 0, 100.0% identity in 886 aa overlap. Also highly similar to many proteins involved in cell division e.g. Escherichia coli SW:FTSK_ECOLI (P46889) (1329 aa), Fasta scores: E(): 0, 43.9% identity in 531 aa overlap and Mycobacterium tuberculosis Rv2748c TR:O33290 (EMBL:AL008967) (883 aa), Fasta scores: E(): 0, 78.1% identity in 885 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FTSK/SPOIIIE FAMILY.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS11444991147159+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0977|ftsK
MIRVIRSSFYPRMLTIDLDAWEETKKQSIASVACSADDIIAIRLVAMASKTVARSGNRTSSLKATSRGVSQSRRPVPPRPRRNRPAERRNQSLLLAAGLTCGQAIRATWLVAAKGAGGAARSIGRARDIEPGHRRDGIALALLGLAVVVAASSWFDAARPIGAWVDAVLRTFIGSAVVVLPLVIAAVAVVLMRTQPNLDTRPRLILGATLIALSFLGLRHLWSGSPETPEVRRGAAGFLGFAIGGPLSDGLTAWIAAPLLFIGALFGLLLLTGTTVREVPEVLRGMFDTGLFQRDYDDQYDAEYRYDDIPGAPPEDFSGCYDGSLVGGGDAEQKVRGWPVTDLAEVSLQDDVPTTPEPAVQAGTAEVHRLTPRSAEEHRTQALDRAIEGSYTLPSMSLLLTGDPPKKCSAANNHMASAIGGVLTQFKVDAAVTGCTRGPTVTRYEVELGPGVKVEKITALQKNIAYAVATESVRMLAPIPGKSAVGIEVPNTDREAVRLADVLTAPSTRRDHHSLVIGLGKDIEGNFISANLAKMPHLLVAGSTGSGKSSFVNSMLVSLLTRSTPEEVRMILIDPKMVELTPYEGIPHLITPIITQPKKAAAALVWLVEEMEQRYQDMQASRVRHIDVFNEKVRSGEITAPLGSQRVYRPYPYILAIVDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQAGAEKLIGMGDGLFLPMGASKPVRLQGAFITDEEIHAVVTACKDQAEPEYTEGVTTAKTTGERTDVDPDIGDDMDVFLQAVELVVSSQFGSTSMLQRKLRVGFAKAGRLMDLMETRSIVGPSEGSKAREVLVKADELAATLALIRGGASADGSNED
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