Gene ML0979
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE PGP SYNTHASE PGSA3 (CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3- PHOSPHATIDYLTRANSFERASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) |
| Comments | ML0979, len: 193 aa. Probable pgsA3, PGP synthase (EC 2.7.8.5). Identical to the previously sequenced Mycobacterium leprae TR:Q49839 (EMBL:U00019) (193 aa), Fasta scores: E(): 0, 100.0% identity in 193 aa overlap. Also highly similar to many phosphatidylglycerophosphate synthases including: Mycobacterium tuberculosis Rv2746c TR:O33288 (EMBL:AL008967) (209 aa), Fasta scores: E(): 0, 77.1% identity in 188 aa overlap and Bacillus subtilis SW:PGSA_BACSU (P46322) (193 aa), Fasta scores: E(): 5.6e-17, 35.8% identity in 193 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1147778 | 1148359 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0979|pgsA3
MVDCVRIANLANILTGLRLMLVPVFLVALFAGNGHEIVGRIAAFVIFTVACITDRLDGLLARRYGMATEFGAFVDPIADKTLIGAALIGLSMLGDLPWWVTVLIMTRELGVTLLRLAVIHRGVIPASWGGKLKTVVQAVAIGLFLLPLTQLSVPFHVGAAVVMAVAVVLTVVTGVDYVAGTIRAVRGVHQTAS
Bibliography
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