Gene ML0995
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | CATALYZES THE FIRST STEP IN THE BIOSYNTHESIS OF 2-METHYLTHIO-N6-(DELTA(2)-ISOPENTENYL)-ADENOSINE (MS[2]I[6]A]) ADJACENT TO THE ANTICODON OF SEVERAL TRNA SPECIES [CATALYTIC ACTIVITY: ISOPENTENYL DIPHOSPHATE + TRNA = PYROPHOSPHATE + TRNA CONTAINING 6-ISOPENTENYLADENOSINE]. |
| Product | PROBABLE TRNA DELTA(2)-ISOPENTENYLPYROPHOSPHATE TRANSFERASE MIAA (IPP TRANSFERASE) (ISOPENTENYL-DIPHOSPHATE:TRNA ISOPENTENYLTRANSFERASE) (IPTASE) (IPPT) |
| Comments | ML0995, len: 311 aa. Probable miaA, tRNA delta(2)-isopentenylpyrophosphate transferase (EC 2.5.1.8) . Identical to the previously sequenced Mycobacterium leprae tRNA delta(2)-isopentenylpyrophosphate transferase (EC 2.5.1.8) SW:MIAA_MYCLE (P46811) (311 aa), Fasta scores: E(): 0, 100.0% identity in 311 aa overlap, as well as several other IPP transferases e.g. from Mycobacterium tuberculosis SW:MIAA_MYCTU (O33232) (314 aa), Fasta scores: E(): 0, 82.2% identity in 314 aa overlap and Escherichia coli SW:MIAA_ECOLI (P16384) (316 aa), Fasta scores: E(): 2.2e-27, 35.5% identity in 293 aa overlap. Contains Pfam match to entry PF01715 IPPT, IPP transferase. Belongs to the IPP transferase family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1163318 | 1164253 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0995|miaA
MRPLAIVGPTGVGKSELALDVIERLGGQVSVEIVNADAMQLYRGMDIGTAKLPVAARRGIPHHQLDVLDVTETATVASYQRTAAADIEAIAARGAVPVVVGGSMLYVQSLLDDWSFPGTDPAVRVRWEQQLAEVGVVRLHAELARRDLAAAAAILPTDGRRTVRALEVVELTGKPFAASAPRIGAPRWDTVIVGLDCDRTILSERLARRIDSMFGQGLVDEVRMLLRWGLRDGVTASRALGYAQVLTALDAGGDADHLDEARQQTYLGHRRYARRQRSWFHRDHRVHWLDVGTVDRVGVVDDALRVWRNAS
Bibliography
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