Gene ML0996
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE DIAMINOPIMELATE EPIMERASE DAPF (DAP EPIMERASE) |
| Comments | ML0996, len: 296 aa. Probable dapF, diaminopimelate epimerase (EC 5.1.1.7). Identical to the previously sequenced Mycobacterium leprae diaminopimelate epimerase (DAP epimerase) involved in the biosynthesis of lysine from aspartate semialdehyde SW:DAPF_MYCLE (P46814) (296 aa), Fasta scores: E(): 0, 100.0% identity in 296 aa overlap. Also highly similar to DAP epimerases from Mycobacterium tuberculosis Rv2726c SW:DAPF_MYCTU (O33231) (289 aa), Fasta scores: E(): 0, 76.0% identity in 292 aa overlap and Escherichia coli SW:DAPF_ECOLI (P08885) (274 aa), Fasta scores: E(): 4.2e-13, 32.3% identity in 294 aa overlap. Contains Pfam match to entry PF01678 DAP_epimerase, Diaminopimelate epimerase. Contains PS01326 Diaminopimelate epimerase signature. Belongs to the diaminopimelate epimerase family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1164320 | 1165210 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0996|dapF
MIFAKGHGTQNDFVVLPDVEADVTFTAAQVAALCNRRQGLGADGVLRVTTAGAAVTAGVLEHLPDGVSCSDWYMDYRNADGSVAQMCGNGVRVFAHYLRASGLESCDEFVVGSLAGPRLVNVHHVDELNADVTVDMGKANLLGSGGPAFAVTVGGRRFSGVAVDVGNPHLACMDPQLSLEELAALDLGAPVHLDRVQFPDGVNIEVLTAPVDGMVQMRVHERGVGETRSCGTGTVAAAVAALASAGADTGTLTVRVPGGDVVITITDVTSYLRGPSVLVAHGELADAWWYSLARSC
Bibliography
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