Gene ML1014c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THE SIGMA FACTOR IS AN INITIATION FACTOR THAT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC INITIATION SITES AND THEN IS RELEASED. MAY CONTROL THE REGULONS OF STATIONARY PHASE AND GENERAL STRESS RESISTANCE. IN M. TUBERCULOSIS IT SEEMS TO BE REGULATED BY SIGH AND SIGE. SEEMS TO REGULATE KATG AND THE HEAT-SHOCK RESPONSE |
| Product | RNA polymerase principal sigma factor SigB |
| Comments | ML1014c, len: 319 aa. Probable sigB, RNA polymerase sigma factorIdentical to the previously sequenced Mycobacterium leprae RNA polymerase sigma factor TR:Q59531 (EMBL:U15181) (319 aa), Fasta scores: E(): 0, 100.0% identity in 319 aa overlap. Also highly similar to many Sigma-70 family proteins e.g. Mycobacterium tuberculosis Rv2710 TR:Q59563 (EMBL:U10059) (323 aa), Fasta scores: E(): 0, 96.2% identity in 316 aa overlap and Streptomyces coelicolor SW:HRDB_STRCO (P18183) (442 aa), Fasta scores: E(): 0, 60.7% identity in 303 aa overlap. Highly similar to the C-terminus of ML1022 from M. leprae. Contains a putative helix-turn-helix motif situated between residues 278..299 (+5.61 SD). Contains a probable helix-turn-helix motif at aa 278-299 (Score 1887, SD +5.61) Contains Pfam match to entry PF00140 sigma70, Sigma-70 factor. Contains PS00716 Sigma-70 factors family signature 2. Contains PS00715 Sigma-70 factors family signature 1. BELONGS TO THE SIGMA-70 FACTOR FAMILY. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1184333 | 1185292 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1014c|sigB
MAEATTNRVDSDLDAQSPAADLVRVYLNGIGKTALLNAADEVELAKRIEAGLYAEHLLQTRKRFGEGRKRALAAVARDGAAARRHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFSTYATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQNLGREATDEELAAESGIPIEKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAMSAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKLFGLSRERVRQIERDVMCKLRNGERADRLRSYAS
Bibliography
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