Gene ML1023c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameppgK
Gene length975 bp
IdentifierML1023c
Location 1190923 bp
Protein summary information
Molecular mass34069.6 Da
Isoelectric point8.82
Protein length325 amino acids
Structural information
PFAMPF00480
Orthologs
M. tuberculosis H37RvRv2702
M. lepromatosis Mx1-22AMLPM_1023
Cross-references
UniProtQ49988
Gene OntologyCytoplasm, Polyphosphate-glucose phosphotransferase activity, Atp binding
Enzyme Classification2.7.1.63
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Productprobable polyphosphate glucokinase PpgK (POLYPHOSPHATE-GLUCOSE PHOSPHOTRANSFERASE)
CommentsML1023c, len: 324 aa. Probable ppgK, polyphosphate glucokinase (EC 2.7.1.63). Identical to the previously sequenced Mycobacterium leprae polyphosphate glucokinase (EC 2.7.1.63) SW:PPGK_MYCLE (Q49988) (324 aa), Fasta scores: E(): 0, 99.7% identity in 324 aa overlap catalysing the phosphorylation of glucose thereby generating D-glucose 6-phosphate. Also highly similar to Mycobacterium tuberculosis Rv2702 SW:PPGK_MYCTU (Q59568) (265 aa), Fasta scores: E(): 0, 82.8% identity in 262 aa overlap. Note the predicted translational start site for this CDS maybe incorrect due to the overlap with CDS ML1024.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS11909231191897-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1023c|ppgK
VIRLRSAAARDRCQVLSLAYRITVAGRCQTVSPHHRQAKVSEQPSLAKEIAITSTDATADTPRTSPPSDTAGTTSRHRGFGIDIGGSSIKGGIVDLDIGQLIGDRIKLLTPQPATPLAVAKTIAEVVNAFGWTAPLGVTYPGVVTQGVVRTAANVDDSWIGTNARDIISAELNSQEVTILNDADAAGLAEGRYGAGKNNSGLIVLLTFGTGIGSAVIHNGKLIPNTEFGHLEVDGKEAEQRAASSVKDKYKWSYRTWAKQVTRVLVAIENAMCPDLFIAGGGISRKADRWIPLLENRTPMVAAALQNTAGIVGAAMASTADVTH
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