Gene ML1024
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). |
| Comments | ML1024, len: 291 aa. Possible subH, inositol monophosphatase. Identical to the previously sequenced Mycobacterium leprae extragenic suppressor protein SuhB homologue SW:SUHB_MYCLE (P46813) (291 aa), Fasta scores: E(): 0, 99.7% identity in 291 aa overlap. Also highly similar to many other members of the inositol monophosphatase family including: Mycobacterium tuberculosis, Rv2701c SW:SUHB_MYCTU (O07203) (290 aa), Fasta scores: E(): 0, 77.6% identity in 294 aa overlap and Escherichia coli ShuB, SW:SUHB_ECOLI (P22783) (267 aa), Fasta scores: E(): 1.6e-18, 34.7% identity in 239 aa overlap, shown to suppress the effect of a temperature-sensitive mutation in E. coli. Note the predicted translational start site for this CDS maybe incorrect due to the overlap with CDS ML1023. Contains Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family. Contains PS00629 Inositol monophosphatase family signature 1. Contains PS00630 Inositol monophosphatase family signature 2. Belongs to the inositol monophosphatase family. |
| Functional category | Virulence, detoxification, adaptation, Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1191846 | 1192721 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1024|suhB
VTVPDNDPEQLRCVAESLATEAAAFVRCRRAEVFGTDLGAAGGGAVRAKSTPTDPVTVVDTETERLLRDRLAQLRPGDSILGEEGGGPADLTATPADTVTWVLDPIDGTVNFVYGIPAYAVSVAAQVDGVSVAGAVAEVVAGRVHSAASGLGAHVTDEYGVQVLRCSAVDDLSMALLGTGFAYSVVRRAAQAALLAQMLPVVRDVRRIGSAALDLCMVAAGQLDAYYEHEVQVWDCAAGALIAAEAGACVQLPKRNGPVGGAGLVVAAAPGIADALLAALQRFNGLAPILD
Bibliography
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