Gene ML1028
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN BIOSYNTHESIS OF THYMIDYLATE. THIS ENZYME IS INVOLVED IN NUCLEOTIDE METABOLISM: IT PRODUCES DUMP, THE IMMEDIATE PRECURSOR OF THYMIDINE NUCLEOTIDES AND IT DECREASES THE INTRACELLULAR CONCENTRATION OF DUTP SO THAT URACIL CANNOT BE INCORPORATED INTO DNA [CATALYTIC ACTIVITY: DUTP + H(2)O = DUMP + PYROPHOSPHATE]. |
| Product | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE DUT (DUTPASE) (DUTP PYROPHOSPHATASE) (DEOXYURIDINE 5'-TRIPHOSPHATASE) (DUTP DIPHOSPHATASE) (DEOXYURIDINE-TRIPHOSPHATASE) |
| Comments | ML1028, len: 154 aa. Probable dut, deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23). Identical to the previously sequenced Mycobacterium leprae deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) SW:DUT_MYCLE (Q49992) (155 aa), Fasta scores: E(): 0, 100.0% identity in 154 aa overlap. Also highly similar to many other dUTPases, involved in nucleotide metabolism, including Mycobacterium tuberculosis SW:DUT_MYCTU (O07199) (154 aa), Fasta scores: E(): 0, 90.3% identity in 154 aa overlap and Escherichia coli SW:DUT_ECOLI (P06968) (461 aa), BlastP Expect 8.8. Contains Pfam match to entry PF00692 dUTPase, dUTPase. BELONGS TO THE DUTPASE FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1194377 | 1194841 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1028|dut
VSTSLAVVRLDPGLPLPSRAHDGDAGVDLYSVEDVKLAPGQRALVRTGLAVAIPFGMVGLIHPRSGLAVRVGLSIVNSPGTVDAGYRGEIKVALINLDPVEPLVVHRGDRIAQLLVQRVELVELVEVSSFDEAGLAETSRGDGGHGSSGGHASL
Bibliography
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