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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionINVOLVED IN BIOSYNTHESIS OF THYMIDYLATE. THIS ENZYME IS INVOLVED IN NUCLEOTIDE METABOLISM: IT PRODUCES DUMP, THE IMMEDIATE PRECURSOR OF THYMIDINE NUCLEOTIDES AND IT DECREASES THE INTRACELLULAR CONCENTRATION OF DUTP SO THAT URACIL CANNOT BE INCORPORATED INTO DNA [CATALYTIC ACTIVITY: DUTP + H(2)O = DUMP + PYROPHOSPHATE].
ProductPROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE DUT (DUTPASE) (DUTP PYROPHOSPHATASE) (DEOXYURIDINE 5'-TRIPHOSPHATASE) (DUTP DIPHOSPHATASE) (DEOXYURIDINE-TRIPHOSPHATASE)
CommentsML1028, len: 154 aa. Probable dut, deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23). Identical to the previously sequenced Mycobacterium leprae deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) SW:DUT_MYCLE (Q49992) (155 aa), Fasta scores: E(): 0, 100.0% identity in 154 aa overlap. Also highly similar to many other dUTPases, involved in nucleotide metabolism, including Mycobacterium tuberculosis SW:DUT_MYCTU (O07199) (154 aa), Fasta scores: E(): 0, 90.3% identity in 154 aa overlap and Escherichia coli SW:DUT_ECOLI (P06968) (461 aa), BlastP Expect 8.8. Contains Pfam match to entry PF00692 dUTPase, dUTPase. BELONGS TO THE DUTPASE FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS11943771194841+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1028|dut
VSTSLAVVRLDPGLPLPSRAHDGDAGVDLYSVEDVKLAPGQRALVRTGLAVAIPFGMVGLIHPRSGLAVRVGLSIVNSPGTVDAGYRGEIKVALINLDPVEPLVVHRGDRIAQLLVQRVELVELVEVSSFDEAGLAETSRGDGGHGSSGGHASL
      
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