Gene ML1040c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1040c
Gene length1290 bp
IdentifierML1040c
Location 1205250 bp
Protein summary information
Molecular mass47348.4 Da
Isoelectric point6.11
Protein length430 amino acids
Structural information
PFAMPF00570, PF01612
Orthologs
M. tuberculosis H37RvRv2681
M. lepromatosis Mx1-22AMLPM_1040
Cross-references
UniProtQ7AQA4
Gene OntologyIntracellular, Nucleic acid binding, Nucleobase-containing compound metabolic process, 3'-5' exonuclease activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Productconserved hypothetical protein
CommentsML1040c, len: 429 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q50004 (EMBL:U15181) (429 aa), Fasta scores: E(): 0, 100.0% identity in 429 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2681 TR:O07183 (EMBL:Z96072) (438 aa), Fasta scores: E(): 0, 77.4% identity in 416 aa overlap. The predicted product of this CDS is also weakly similar to several nucleases e.g. Escherichia coli SW:RND_ECOLI (P09155) (375 aa), Fasta scores: E(): 2.4e-08, 26.7% identity in 371 aa overlap ribonuclease D (EC 3.1.26.3). Contains Pfam match to entry PF01612 3_5_exonuclease, 3'-5' exonuclease.
Functional categoryConserved hypotheticals
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS12052501206539-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1040c|ML1040c
MREPADDQPGGTEPDPTPLHYPAGGIPNLSVTPSEIAAAAERLDQGYGPFAVDTERASGFRYSNRAYLIQIRRANAGTVLIDPVSHGNDPLTALRPVAEVISKDEWILHSADQDLPCLAEVGMRPPALYDTELAGRLAGFDRVNLATMVQRLLGFELAKGHGAADWSKRPLPSDWLNYAALDVELLIELRTAISKVLAEQDKTDWATQEFNYLRTYATRGATTETIPPTRRDRWRRTSGIRRVRDRRALAAVRELWATRDHIAQRRDIAPRRILPDTAIIDAAIADPKTIDELIAMPVFGGANQRRSAAMWLAALETARQSQDLPDEAEPSNVPPPPGRWARRKPDAAARLEAARAALATVSQRVGVPTENLVSPELVRRLCWDWEVLPESSVDPVNAVEEYLRVGQARAWQRELVVTILASAVKSSAG
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