Gene ML1043
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE UROPORPHYRINOGEN DECARBOXYLASE HEME (UROPORPHYRINOGEN III DECARBOXYLASE) (URO-D) (UPD) |
| Comments | ML1043, len: 357 aa. Probable hemE, uroporphyrinogen decarboxylase (EC 4.1.1.37). Identical to the previously sequenced Mycobacterium leprae uroporphyrinogen decarboxylase (EC 4.1.1.37) SW:DCUP_MYCLE (P46809) (357 aa), Fasta scores: E(): 0, 100.0% identity in 357 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis SW:DCUP_MYCTU (O53231) (357 aa), Fasta scores: E(): 0, 83.8% identity in 357 aa overlap and Bacillus subtilis SW:DCUP_BACSU (P32395) (353 aa), Fasta scores: E(): 0, 43.5% identity in 354 aa overlap. Contains Pfam match to entry PF01208 URO-D, Uroporphyrinogen decarboxylase (URO-D). Contains PS00907 Uroporphyrinogen decarboxylase signature 2. Contains PS00906 Uroporphyrinogen decarboxylase signature 1. Belongs to the uroporphyrinogen decarboxylase family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1208220 | 1209293 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1043|hemE
MSTRRELLESPYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPEVACEITLQPLRRYDVDAAILFSDIVVPLCAAGIDLDIVPDVGPVIGDPVRTATDIHAMKPLEPQAIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGPSRNHPRTKAMMLAEPASWHTLMDKLTDLTLGFLLGQIDAGVDAIQVFDSWAGTLSLSDYRQYVLPHSARIFATVAEHGVPMTHFGVGTADLLGAMSAAVRSGEKPGHQAVVGVDWRTSLTDAAARVEPCTALQGNLDPVVLLAGWPAVERVARTVVDDGRRAVVAGAAGHVFNLGHGVLPETDPGVLSELVSFIHSL
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